Literature DB >> 8467996

A yeast gene for trehalose-6-phosphate synthase and its complementation of an Escherichia coli otsA mutant.

J McDougall1, I Kaasen, A R Strøm.   

Abstract

A Saccharomyces cerevisiae gene for trehalose-6-phosphate synthase (TPS1) was sequenced. The gene appeared to code for a protein of 495 amino acid residues, giving the protein a molecular mass of 56 kDa. The TPS1 gene was able to restore both osmotolerance and trehalose accumulation during salt stress in an Escherichia coli strain mutated in the otsA gene encoding trehalose-6-phosphate synthase. Complementation studies with E. coli galU mutants showed that the TPS1-encoded trehalose-6-phosphate synthase is UDP-glucose-dependent. Sequence analysis and data base searches showed that TPS1 is allelic to GGS1, byp1, cif1 and fdp1. A possible gene for trehalose-6-phosphate synthase in Methanobacterium thermoautotrophicum was identified.

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Year:  1993        PMID： 8467996     DOI： 10.1016/0378-1097(93)90348-6

Source DB:  PubMed          Journal:  FEMS Microbiol Lett        ISSN： 0378-1097            Impact factor:   2.742


  9 in total

1.  A glycine betaine importer limits Salmonella stress resistance and tissue colonization by reducing trehalose production.

Authors:  M Carolina Pilonieta; Toni A Nagy; Dana R Jorgensen; Corrella S Detweiler
Journal:  Mol Microbiol       Date:  2012-03-09       Impact factor: 3.501

2.  Regulation of genes encoding subunits of the trehalose synthase complex in Saccharomyces cerevisiae: novel variations of STRE-mediated transcription control?

Authors:  J Winderickx; J H de Winde; M Crauwels; A Hino; S Hohmann; P Van Dijck; J M Thevelein
Journal:  Mol Gen Genet       Date:  1996-09-25

Review 3.  Central Role of the Trehalose Biosynthesis Pathway in the Pathogenesis of Human Fungal Infections: Opportunities and Challenges for Therapeutic Development.

Authors:  Arsa Thammahong; Srisombat Puttikamonkul; John R Perfect; Richard G Brennan; Robert A Cramer
Journal:  Microbiol Mol Biol Rev       Date:  2017-03-15       Impact factor: 11.056

4.  Trehalose-6-P synthase is dispensable for growth on glucose but not for spore germination in Schizosaccharomyces pombe.

Authors:  M A Blázquez; R Stucka; H Feldmann; C Gancedo
Journal:  J Bacteriol       Date:  1994-07       Impact factor: 3.490

Review 5.  Revisiting yeast trehalose metabolism.

Authors:  Elis Eleutherio; Anita Panek; Joelma Freire De Mesquita; Eduardo Trevisol; Rayne Magalhães
Journal:  Curr Genet       Date:  2014-09-11       Impact factor: 3.886

6.  Differential importance of trehalose in stress resistance in fermenting and nonfermenting Saccharomyces cerevisiae cells.

Authors:  P Van Dijck; D Colavizza; P Smet; J M Thevelein
Journal:  Appl Environ Microbiol       Date:  1995-01       Impact factor: 4.792

7.  The byp1-3 allele of the Saccharomyces cerevisiae GGS1/TPS1 gene and its multi-copy suppressor tRNA(GLN) (CAG): Ggs1/Tps1 protein levels restraining growth on fermentable sugars and trehalose accumulation.

Authors:  S Hohmann; P Van Dijck; K Luyten; J M Thevelein
Journal:  Curr Genet       Date:  1994-10       Impact factor: 3.886

8.  Control of glucose influx into glycolysis and pleiotropic effects studied in different isogenic sets of Saccharomyces cerevisiae mutants in trehalose biosynthesis.

Authors:  M J Neves; S Hohmann; W Bell; F Dumortier; K Luyten; J Ramos; P Cobbaert; W de Koning; Z Kaneva; J M Thevelein
Journal:  Curr Genet       Date:  1995-01       Impact factor: 3.886

9.  Fps1, a yeast member of the MIP family of channel proteins, is a facilitator for glycerol uptake and efflux and is inactive under osmotic stress.

Authors:  K Luyten; J Albertyn; W F Skibbe; B A Prior; J Ramos; J M Thevelein; S Hohmann
Journal:  EMBO J       Date:  1995-04-03       Impact factor: 11.598
  9 in total

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