Literature DB >> 8467864

Inhibition of cytokine production and endothelial expression of adhesion antigens by 5'-methylthioadenosine.

M A Cerri1, A Beltrán-Nuñez, S Bernasconi, E Dejana, L Bassi, G Bazzoni.   

Abstract

We investigated the activity of endogenous nucleoside 5'-deoxy-5'-methylthioadenosine (MTA) on both the production of inflammatory cytokines and the cytokine-dependent endothelial expression of adhesion molecules. The compound inhibited the production of tumor necrosis factor (but not interleukin-1) in lipopolysaccharide-activated macrophages. In addition, MTA selectively inhibited the expression of intercellular adhesion molecule-1 in endothelial cells activated with interleukin-1. This effect was paralleled by a reduction in endothelial adhesiveness for polymorphonuclear leukocytes. These data suggest that MTA might have anti-inflammatory activity.

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Year:  1993        PMID： 8467864     DOI： 10.1016/0014-2999(93)90787-i

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  6 in total

1.  Down-regulation of methylthioadenosine phosphorylase (MTAP) induces progression of hepatocellular carcinoma via accumulation of 5'-deoxy-5'-methylthioadenosine (MTA).

Authors:  Georgi Kirovski; Axel P Stevens; Barbara Czech; Katja Dettmer; Thomas S Weiss; Peter Wild; Arndt Hartmann; Anja K Bosserhoff; Peter J Oefner; Claus Hellerbrand
Journal:  Am J Pathol       Date:  2011-01-28       Impact factor: 4.307

Review 2.  Methylthioadenosine/S-adenosylhomocysteine nucleosidase, a critical enzyme for bacterial metabolism.

Authors:  Nikhat Parveen; Kenneth A Cornell
Journal:  Mol Microbiol       Date:  2010-11-18       Impact factor: 3.501

3.  Preventative oral methylthioadenosine is anti-inflammatory and reduces DSS-induced colitis in mice.

Authors:  Nancy M Benight; Barbara Stoll; Juan C Marini; Douglas G Burrin
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2012-05-03       Impact factor: 4.052

4.  Metabolic Regulation as a Consequence of Anaerobic 5-Methylthioadenosine Recycling in Rhodospirillum rubrum.

Authors:  Justin A North; Jaya Sriram; Karuna Chourey; Christopher D Ecker; Ritin Sharma; John A Wildenthal; Robert L Hettich; F Robert Tabita
Journal:  MBio       Date:  2016-07-12       Impact factor: 7.867

Review 5.  5'-Methylthioadenosine and Cancer: old molecules, new understanding.

Authors:  Yaofeng Li; Yubo Wang; Ping Wu
Journal:  J Cancer       Date:  2019-01-29       Impact factor: 4.207

6.  Serum metabolites associate with physical performance among middle-aged adults: Evidence from the Bogalusa Heart Study.

Authors:  Jovia L Nierenberg; Jiang He; Changwei Li; Xiaoying Gu; Mengyao Shi; Alexander C Razavi; Xuenan Mi; Shengxu Li; Lydia A Bazzano; Amanda H Anderson; Hua He; Wei Chen; Jack M Guralnik; Jason M Kinchen; Tanika N Kelly
Journal:  Aging (Albany NY)       Date:  2020-06-01       Impact factor: 5.682
  6 in total

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