| Literature DB >> 8467709 |
H H van Es1, A Bout, J Liu, L Anderson, A M Duncan, P Bosma, R Oude Elferink, P L Jansen, J R Chowdhury, E Schurr.
Abstract
UDP glucuronosyltransferases (UGTs) comprise a multigene family of drug-metabolizing enzymes. The sub-family of UGTs that conjugate bilirubin and phenolic compounds with glucuronic acid has been termed UGT1A1. In man, UGT1A1 isoforms are encoded by a single gene, UGT1A1. Protein isoforms encoded by UGT1A1 originate by alternative splicing. In the present study, we used the cDNA of UGT1A1*4, a bilirubin-conjugating isoform, to localize the UGT1A1 locus in the human genome. The UGT1A1 gene was assigned by in situ hybridization to chromosome region 2q37.Entities:
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Year: 1993 PMID： 8467709 DOI： 10.1159/000133513
Source DB: PubMed Journal: Cytogenet Cell Genet ISSN： 0301-0171