Literature DB >> 8466953

Effect of fluvastatin sodium (XU62-320), a new inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, on the induction of low-density lipoprotein receptor in HepG2 cells.

K Hayashi1, J Kurokawa, S Nomura, Y Kuga, Y Ohkura, G Kajiyama.   

Abstract

The effect of fluvastatin sodium (XU62-320), a new type of inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A, on the induction of LDL receptor in the human liver-derived cell line HepG2 was investigated. Fluvastatin sodium produced marked inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and induction of LDL receptor on HepG2 cells at a concentration of 0.1-1.0 microM. These results suggest that fluvastatin sodium has potential for use as a strong plasma cholesterol-lowering drug.

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Year:  1993        PMID： 8466953     DOI： 10.1016/0005-2760(93)90166-7

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  6 in total

1.  Simvastatin potentiates the anti-hepatitis B virus activity of FDA-approved nucleoside analogue inhibitors in vitro.

Authors:  Ted Bader; Brent Korba
Journal:  Antiviral Res       Date:  2010-03-06       Impact factor: 5.970

Review 2.  Fluvastatin: a review of its pharmacology and use in the management of hypercholesterolaemia.

Authors:  G L Plosker; A J Wagstaff
Journal:  Drugs       Date:  1996-03       Impact factor: 9.546

Review 3.  Clinical pharmacokinetics of fluvastatin.

Authors:  C D Scripture; J A Pieper
Journal:  Clin Pharmacokinet       Date:  2001       Impact factor: 6.447

4.  Inhibition of cholesterol synthesis ex vivo and in vivo by fluvastatin, a new inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase.

Authors:  A Yamamoto; S Itoh; K Hoshi; K Ichihara
Journal:  Experientia       Date:  1995-03-15

5.  Antiproliferative effect of fluvastatin and thiazolidinedione in mesangial cells of diabetic rats.

Authors:  Mitsuru Okada; Hidehiko Yanagida; Hiroaki Kuwajima; Tsukasa Takemura
Journal:  Pediatr Nephrol       Date:  2003-11-22       Impact factor: 3.714

6.  Interferon-γ-induced HLA Class II expression on endothelial cells is decreased by inhibition of mTOR and HMG-CoA reductase.

Authors:  Akihiro Maenaka; Iwasaki Kenta; Akinobu Ota; Yuko Miwa; Wataru Ohashi; Kosei Horimi; Yutaka Matsuoka; Masafumi Ohnishi; Kazuharu Uchida; Takaaki Kobayashi
Journal:  FEBS Open Bio       Date:  2020-04-15       Impact factor: 2.693
  6 in total

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