Literature DB >> 8466528

The mouse low density lipoprotein receptor gene: cDNA sequence and exon-intron structure.

M J Hoffer1, M M van Eck, F Petrij, A van der Zee, E de Wit, D Meijer, G Grosveld, L M Havekes, M H Hofker, R R Frants.   

Abstract

The low density lipoprotein (LDL) receptor plays a central role in the cholesterol metabolism. The cDNA sequence of the mouse low density lipoprotein receptor (Ldlr) gene has been determined and shows 76% homology with the human gene. The exon-intron structure has been determined for the 129/J mouse strain. The gene is composed of 18 exons and spans a region of 28 kb. In addition, the promoter regions of the mouse and human genes are homologous. Northern blot analysis revealed an mRNA of approximately 5 kb. The cloning of the Ldlr gene will enhance the usefulness of the mouse for the study of cholesterol metabolism and, in particular, for carrying out gene targeting experiments.

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Year:  1993        PMID： 8466528     DOI： 10.1006/bbrc.1993.1299

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  5 in total

1.  Identification of essential nucleotides of the FP1 element responsible for enhancement of low density lipoprotein receptor gene transcription.

Authors:  P Dhawan; R Chang; K D Mehta
Journal:  Nucleic Acids Res       Date:  1997-10-15       Impact factor: 16.971

2.  Hypercholesterolemia induces angiogenesis and accelerates growth of breast tumors in vivo.

Authors:  Kristine Pelton; Christine M Coticchia; Adam S Curatolo; Carl P Schaffner; David Zurakowski; Keith R Solomon; Marsha A Moses
Journal:  Am J Pathol       Date:  2014-07       Impact factor: 4.307

3.  Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells.

Authors:  I Shimomura; H Shimano; J D Horton; J L Goldstein; M S Brown
Journal:  J Clin Invest       Date:  1997-03-01       Impact factor: 14.808

4.  Modulation of very low density lipoprotein production and clearance contributes to age- and gender- dependent hyperlipoproteinemia in apolipoprotein E3-Leiden transgenic mice.

Authors:  B J van Vlijmen; H B van 't Hof; M J Mol; H van der Boom; A van der Zee; R R Frants; M H Hofker; L M Havekes
Journal:  J Clin Invest       Date:  1996-03-01       Impact factor: 14.808

5.  Chicken oocyte growth is mediated by an eight ligand binding repeat member of the LDL receptor family.

Authors:  H Bujo; M Hermann; M O Kaderli; L Jacobsen; S Sugawara; J Nimpf; T Yamamoto; W J Schneider
Journal:  EMBO J       Date:  1994-11-01       Impact factor: 11.598
  5 in total

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