BACKGROUND AND PURPOSE: Very few studies have addressed the identification of prognostic factors in patients with a transient ischemic attack or minor stroke. METHODS: We prospectively studied the prognostic value of clinical, laboratory, radiological, and electrocardiographic findings in 997 patients with a transient ischemic attack and 2,130 patients with a minor stroke who were entered into a multicenter clinical trial. The mean follow-up period was 2.6 years. RESULTS: A total of 302 patients died (212 from a vascular cause), 272 had a stroke, and 200 had a cardiac event. By means of a multivariate analysis we identified the following independent risk factors for stroke, myocardial infarction, or vascular death: age of > 65 years; male sex; dysarthria; multiple attacks; diabetes; angina pectoris; intermittent claudication; computed tomographic evidence of any cerebral infarct, especially a border zone infarct or white matter hypodensity; and electrocardiographic evidence of an anteroseptal infarct, ST depression, left ventricular hypertrophy, or left atrial conduction delay. Protective predictors were monocular attacks only or the presence of rotatory dizziness. CONCLUSION: A limited number of easily obtainable characteristics are powerful predictors of major vascular events in patients with cerebral ischemia.
RCT Entities:
BACKGROUND AND PURPOSE: Very few studies have addressed the identification of prognostic factors in patients with a transient ischemic attack or minor stroke. METHODS: We prospectively studied the prognostic value of clinical, laboratory, radiological, and electrocardiographic findings in 997 patients with a transient ischemic attack and 2,130 patients with a minor stroke who were entered into a multicenter clinical trial. The mean follow-up period was 2.6 years. RESULTS: A total of 302 patients died (212 from a vascular cause), 272 had a stroke, and 200 had a cardiac event. By means of a multivariate analysis we identified the following independent risk factors for stroke, myocardial infarction, or vascular death: age of > 65 years; male sex; dysarthria; multiple attacks; diabetes; angina pectoris; intermittent claudication; computed tomographic evidence of any cerebral infarct, especially a border zone infarct or white matter hypodensity; and electrocardiographic evidence of an anteroseptal infarct, ST depression, left ventricular hypertrophy, or left atrial conduction delay. Protective predictors were monocular attacks only or the presence of rotatory dizziness. CONCLUSION: A limited number of easily obtainable characteristics are powerful predictors of major vascular events in patients with cerebral ischemia.
Authors: Omar M Al-Janabi; Christopher A Brown; Ahmed A Bahrani; Erin L Abner; Justin M Barber; Brian T Gold; Larry B Goldstein; Ronan R Murphy; Peter T Nelson; Nathan F Johnson; Leslie M Shaw; Charles D Smith; John Q Trojanowski; Donna M Wilcock; Gregory A Jicha Journal: J Alzheimers Dis Date: 2018 Impact factor: 4.472
Authors: E L L M De Schryver; A Algra; R C J M Donders; J van Gijn; L J Kappelle Journal: J Neurol Neurosurg Psychiatry Date: 2006-02-24 Impact factor: 10.154
Authors: T J Tegos; M Sohail; M M Sabetai; P Robless; N Akbar; G Pare; G Stansby; A N Nicolaides Journal: AJNR Am J Neuroradiol Date: 2000 Nov-Dec Impact factor: 3.825
Authors: Judith H Lichtman; Sara B Jones; Emi Watanabe; Norrina B Allen; Yun Wang; Virginia J Howard; Larry B Goldstein Journal: Stroke Date: 2009-02-19 Impact factor: 7.914