D Eisen1. 1. Dermatology Associates of Cincinnati, Inc., OH 45230.
Abstract
BACKGROUND: Oral lichen planus is chronic and can be debilitating. Topical corticosteroids are most frequently used for treatment, but they are not always effective. OBJECTIVE:Hydroxychloroquine sulfate (Plaquenil), an antimalarial agent, was evaluated in an open trial (10 patients) for its ability to improve oral lichen planus. METHODS: Patients received hydroxychloroquine, 200 to 400 mg daily, as a monotherapy for 6 months. Patients were assessed at baseline and every 4 to 8 weeks during treatment. Baseline ophthalmologic examinations were performed, and laboratory values were monitored before and during treatment. RESULTS: Nine of ten patients had an excellent response to therapy. Three of six patients with erosions at baseline had complete healing. Pain relief and reduced erythema were usually observed after 1 to 2 months of therapy, but erosions required 3 to 6 months of treatment before they resolved. There were no adverse effects. CONCLUSION:Hydroxychloroquine may be useful in the treatment of oral lichen planus.
RCT Entities:
BACKGROUND: Oral lichen planus is chronic and can be debilitating. Topical corticosteroids are most frequently used for treatment, but they are not always effective. OBJECTIVE:Hydroxychloroquine sulfate (Plaquenil), an antimalarial agent, was evaluated in an open trial (10 patients) for its ability to improve oral lichen planus. METHODS:Patients received hydroxychloroquine, 200 to 400 mg daily, as a monotherapy for 6 months. Patients were assessed at baseline and every 4 to 8 weeks during treatment. Baseline ophthalmologic examinations were performed, and laboratory values were monitored before and during treatment. RESULTS: Nine of ten patients had an excellent response to therapy. Three of six patients with erosions at baseline had complete healing. Pain relief and reduced erythema were usually observed after 1 to 2 months of therapy, but erosions required 3 to 6 months of treatment before they resolved. There were no adverse effects. CONCLUSION:Hydroxychloroquine may be useful in the treatment of oral lichen planus.
Authors: Arthur Schmouchkovitch; Héloïse Herry; Philippe Thuillier; Véronique Kerlan; Camille Fleuret; Guy Le Toux; Sylvie Boisramé Journal: Medicine (Baltimore) Date: 2017-01 Impact factor: 1.889
Authors: Dario Didona; Raffaele Dante Caposiena Caro; Antonio Manuel Sequeira Santos; Farzan Solimani; Michael Hertl Journal: Front Med (Lausanne) Date: 2022-10-04