Literature DB >> 8462974

A new human brain cDNA molecule: assignment to chromosome 11q21-q23.1 and description of two polymorphisms studied by the polymerase chain reaction.

S Lefebvre1, J F Bureau, F Muscatelli, M G Mattei, M Brahic.   

Abstract

A new human brain cDNA molecule was mapped by in situ hybridization to the 11q21-q23.1 region of the human genome, probably to the 11q22 band. An EcoRI restriction site and a (GT)n repeat element within the gene were shown to be polymorphic. Both polymorphisms were readily studied by the polymerase chain reaction. A two-allele polymorphism was described for the EcoRI restriction site, whereas four different alleles were detected for the second genetic marker. The observed heterozygosities were 37% and 42% for the former and the latter polymorphism, respectively. The combined heterozygosity index was estimated to be 0.56. These new genetic markers will be useful for linkage analysis of neurogenetic diseases that have been mapped to this chromosomal region.

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Year:  1993        PMID： 8462974     DOI： 10.1007/bf00222715

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  9 in total

1.  Chromosomal assignment of 46 brain cDNAs.

Authors:  M H Polymeropoulos; H Xiao; A Glodek; M Gorski; M D Adams; R F Moreno; M G Fitzgerald; J C Venter; C R Merril
Journal:  Genomics       Date:  1992-03       Impact factor: 5.736

2.  The human dopamine D2 receptor gene is located on chromosome 11 at q22-q23 and identifies a TaqI RFLP.

Authors:  D K Grandy; M Litt; L Allen; J R Bunzow; M Marchionni; H Makam; L Reed; R E Magenis; O Civelli
Journal:  Am J Hum Genet       Date:  1989-11       Impact factor: 11.025

3.  DNA probe localization at 18p113 band by in situ hybridization and identification of a small supernumerary chromosome.

Authors:  M G Mattei; N Philip; E Passage; J P Moisan; J L Mandel; J F Mattei
Journal:  Hum Genet       Date:  1985       Impact factor: 4.132

4.  Ataxia-telangiectasia: linkage analysis in highly inbred Arab and Druze families and differentiation from an ataxia-microcephaly-cataract syndrome.

Authors:  Y Ziv; M Frydman; E Lange; N Zelnik; G Rotman; C Julier; N G Jaspers; Y Dagan; D Abeliovicz; H Dar; Z Borochowitz; M Lathrop; R A Gatti; Y Shiloh
Journal:  Hum Genet       Date:  1992-03       Impact factor: 4.132

5.  Cytogenetic characterization of selected small round cell tumors of childhood.

Authors:  J Whang-Peng; T J Triche; T Knutsen; J Miser; S Kao-Shan; S Tsai; M A Israel
Journal:  Cancer Genet Cytogenet       Date:  1986-04-01

6.  Analysis of 7 polymorphic markers at chromosome 11q22-23 in 35 ataxia telangiectasia families; further evidence of linkage.

Authors:  C M McConville; C G Woods; M Farrall; J A Metcalfe; A M Taylor
Journal:  Hum Genet       Date:  1990-07       Impact factor: 4.132

7.  The ataxia-telangiectasia gene (ATA) on chromosome II is distinct from the ETS-1 gene.

Authors:  P Concannon; U Malhotra; P Charmley; J Reynolds; K Lange; R A Gatti
Journal:  Am J Hum Genet       Date:  1990-04       Impact factor: 11.025

8.  Report of the second chromosome 11 workshop.

Authors:  C Junien; V van Heyningen; G Evans; P Little; M Mannens
Journal:  Genomics       Date:  1992-03       Impact factor: 5.736

9.  Localization of the human NCAM gene to band q23 of chromosome 11: the third gene coding for a cell interaction molecule mapped to the distal portion of the long arm of chromosome 11.

Authors:  C Nguyen; M G Mattei; J F Mattei; M J Santoni; C Goridis; B R Jordan
Journal:  J Cell Biol       Date:  1986-03       Impact factor: 10.539
  9 in total

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