Literature DB >> 8462734

Expression of the SmN splicing protein is developmentally regulated in the rodent brain but not in the rodent heart.

K Grimaldi1, D A Horn, L D Hudson, G Terenghi, P Barton, J M Polak, D S Latchman.   

Abstract

The SmN protein is a tissue-specific splicing factor which is closely related to the ubiquitous SmB splicing protein but which is expressed only in the adult brain and heart. SmN is also detectable albeit at a low level in both the embryonic brain and heart. During heart development, SmN levels remain constant while during rodent brain development the levels of SmN rise such that SmN replaces SmB as the predominant protein in adult brain. This increase in SmN levels is dependent upon a corresponding increase in the SmN mRNA which is detectable by in situ hybridization within neurons in virtually all areas of the adult brain.

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Year:  1993        PMID： 8462734     DOI： 10.1006/dbio.1993.1080

Source DB:  PubMed          Journal:  Dev Biol        ISSN： 0012-1606            Impact factor:   3.582


  8 in total

1.  Regulation of alternative splicing by the core spliceosomal machinery.

Authors:  Arneet L Saltzman; Qun Pan; Benjamin J Blencowe
Journal:  Genes Dev       Date:  2011-02-15       Impact factor: 11.361

2.  Ubiquitous expression and imprinting of Snrpn in the mouse.

Authors:  J A Barr; J Jones; P H Glenister; B M Cattanach
Journal:  Mamm Genome       Date:  1995-06       Impact factor: 2.957

3.  Imprinting-mutation mechanisms in Prader-Willi syndrome.

Authors:  T Ohta; T A Gray; P K Rogan; K Buiting; J M Gabriel; S Saitoh; B Muralidhar; B Bilienska; M Krajewska-Walasek; D J Driscoll; B Horsthemke; M G Butler; R D Nicholls
Journal:  Am J Hum Genet       Date:  1999-02       Impact factor: 11.025

4.  Gene structure, DNA methylation, and imprinted expression of the human SNRPN gene.

Authors:  C C Glenn; S Saitoh; M T Jong; M M Filbrandt; U Surti; D J Driscoll; R D Nicholls
Journal:  Am J Hum Genet       Date:  1996-02       Impact factor: 11.025

5.  An imprinted, mammalian bicistronic transcript encodes two independent proteins.

Authors:  T A Gray; S Saitoh; R D Nicholls
Journal:  Proc Natl Acad Sci U S A       Date:  1999-05-11       Impact factor: 11.205

Review 6.  Mice lacking Snrpn expression show normal regulation of neuronal alternative splicing events.

Authors:  J D Huntriss; J A Barr; D A Horn; D G Williams; D S Latchman
Journal:  Mol Biol Rep       Date:  1994-07       Impact factor: 2.316

7.  The autism-related gene SNRPN regulates cortical and spine development via controlling nuclear receptor Nr4a1.

Authors:  Huiping Li; Pingping Zhao; Qiong Xu; Shifang Shan; Chunchun Hu; Zilong Qiu; Xiu Xu
Journal:  Sci Rep       Date:  2016-07-19       Impact factor: 4.379

8.  Tissue-specific splicing factor gene expression signatures.

Authors:  Ana Rita Grosso; Anita Q Gomes; Nuno L Barbosa-Morais; Sandra Caldeira; Natalie P Thorne; Godfrey Grech; Marieke von Lindern; Maria Carmo-Fonseca
Journal:  Nucleic Acids Res       Date:  2008-07-24       Impact factor: 16.971
  8 in total

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