Literature DB >> 8461920

Osteoarthritic human cartilage is more sensitive to transforming growth factor beta than is normal cartilage.

F P Lafeber1, P M Vander Kraan, O Huber-Bruning, W B Vanden Berg, J W Bijlsma.   

Abstract

Osteoarthritis is a degenerative joint disease, characterized by the destruction of the articular cartilage. One of the first changes in the osteoarthritic articular cartilage is a reduction in proteoglycan content. In this study we demonstrate that transforming growth factor beta (TGF beta), a multi-functional growth factor, stimulates the proteoglycan synthesis of explants from human articular knee cartilage dose-dependently in vitro. Osteoarthritic cartilage proved to be much more sensitive to stimulation by TGF beta than normal healthy cartilage. This may indicate that TGF beta plays an important role in the repair of osteoarthritic cartilage.

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Year:  1993        PMID： 8461920     DOI： 10.1093/rheumatology/32.4.281

Source DB:  PubMed          Journal:  Br J Rheumatol        ISSN： 0263-7103


  13 in total

1.  Effects of transforming growth factor beta s and basic fibroblast growth factor on articular chondrocytes obtained from immobilised rabbit knees.

Authors:  R Okazaki; A Sakai; T Nakamura; N Kunugita; T Norimura; K Suzuki
Journal:  Ann Rheum Dis       Date:  1996-03       Impact factor: 19.103

2.  Loss of transforming growth factor counteraction on interleukin 1 mediated effects in cartilage of old mice.

Authors:  A Scharstuhl; H M van Beuningen; E L Vitters; P M van der Kraan; W B van den Berg
Journal:  Ann Rheum Dis       Date:  2002-12       Impact factor: 19.103

3.  F-spondin, a neuroregulatory protein, is up-regulated in osteoarthritis and regulates cartilage metabolism via TGF-beta activation.

Authors:  Mukundan G Attur; Glyn D Palmer; Hayf E Al-Mussawir; Mandar Dave; Cristina C Teixeira; Daniel B Rifkin; C Thomas G Appleton; Frank Beier; Steven B Abramson
Journal:  FASEB J       Date:  2008-09-09       Impact factor: 5.191

4.  In vivo protection against interleukin-1-induced articular cartilage damage by transforming growth factor-beta 1: age-related differences.

Authors:  H M van Beuningen; P M van der Kraan; O J Arntz; W B van den Berg
Journal:  Ann Rheum Dis       Date:  1994-09       Impact factor: 19.103

5.  Accumulation of exogenous activated TGF-β in the superficial zone of articular cartilage.

Authors:  Michael B Albro; Robert J Nims; Alexander D Cigan; Kevin J Yeroushalmi; Tamara Alliston; Clark T Hung; Gerard A Ateshian
Journal:  Biophys J       Date:  2013-04-16       Impact factor: 4.033

Review 6.  Trophic factors in aging. Should older people receive hormonal replacement therapy?

Authors:  D T Villareal; J E Morley
Journal:  Drugs Aging       Date:  1994-06       Impact factor: 3.923

7.  Chondrocyte number and proteoglycan synthesis in the aging and osteoarthritic human articular cartilage.

Authors:  K Bobacz; L Erlacher; J Smolen; A Soleiman; W B Graninger
Journal:  Ann Rheum Dis       Date:  2004-12       Impact factor: 19.103

8.  Differential direct effects of cyclo-oxygenase-1/2 inhibition on proteoglycan turnover of human osteoarthritic cartilage: an in vitro study.

Authors:  Simon C Mastbergen; Nathalie W D Jansen; Johannes W J Bijlsma; Floris P J G Lafeber
Journal:  Arthritis Res Ther       Date:  2006       Impact factor: 5.156

9.  TGF-beta/Smad3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilage.

Authors:  X Yang; L Chen; X Xu; C Li; C Huang; C X Deng
Journal:  J Cell Biol       Date:  2001-04-02       Impact factor: 10.539

10.  A role for subchondral bone changes in the process of osteoarthritis; a micro-CT study of two canine models.

Authors:  Yvonne H Sniekers; Femke Intema; Floris P J G Lafeber; Gerjo J V M van Osch; Johannes P T M van Leeuwen; Harrie Weinans; Simon C Mastbergen
Journal:  BMC Musculoskelet Disord       Date:  2008-02-12       Impact factor: 2.362
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