Literature DB >> 8460638

Linkage of a major breast cancer gene to chromosome 17q12-21: results from 15 Edinburgh families.

B B Cohen1, D E Porter, M R Wallace, A Carothers, C M Steel.   

Abstract

DNA from members of 15 pedigrees each containing between three and eight cases of breast cancer have been collected from southeastern Scotland. Polymorphic markers on chromosome 17q were screened to locate a putative breast cancer gene by using DNA from relevant individuals within these families. Pairwise LOD scores were calculated for markers D17S74, NM23, D17S588, and D17S579. The maximal summated LOD for the 15 families was 5.44 at theta = .034, when D17S588 (42D6) was used. In these breast cancer families, a subset which did not give evidence for linkage to this region could be identified.

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Year:  1993        PMID： 8460638      PMCID： PMC1682086     

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN： 0002-9297            Impact factor:   11.025


  9 in total

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Authors:  B B Cohen; M R Wallace; D N Crichton
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2.  Regional localization of the gene for cardiac muscle actin (ACTC) on chromosome 15q.

Authors:  P L Kramer; J A Luty; M Litt
Journal:  Genomics       Date:  1992-07       Impact factor: 5.736

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Authors:  C M Steel
Journal:  Lancet       Date:  1984-10-27       Impact factor: 79.321

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Authors:  J M Hall; M K Lee; B Newman; J E Morrow; L A Anderson; B Huey; M C King
Journal:  Science       Date:  1990-12-21       Impact factor: 47.728

6.  Genetic epidemiology of breast cancer in Britain.

Authors:  L Iselius; J Slack; M Littler; N E Morton
Journal:  Ann Hum Genet       Date:  1991-05       Impact factor: 1.670

7.  Southern blot analysis of DNA extracted from paraffin wax-embedded tissue.

Authors:  M R MacDonald; B B Cohen
Journal:  Dis Markers       Date:  1990 Nov-Dec       Impact factor: 3.434

8.  Endometrial carcinoma in the cancer family syndrome.

Authors:  T Hakala; J P Mecklin; M Forss; H Järvinen; P Lehtovirta
Journal:  Cancer       Date:  1991-10-01       Impact factor: 6.860

9.  Genetic analysis of breast cancer in the cancer and steroid hormone study.

Authors:  E B Claus; N Risch; W D Thompson
Journal:  Am J Hum Genet       Date:  1991-02       Impact factor: 11.025
  9 in total
  7 in total

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Journal:  Am J Hum Genet       Date:  1996-07       Impact factor: 11.025

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3.  Genetic linkage analysis in familial breast and ovarian cancer: results from 214 families. The Breast Cancer Linkage Consortium.

Authors:  D F Easton; D T Bishop; D Ford; G P Crockford
Journal:  Am J Hum Genet       Date:  1993-04       Impact factor: 11.025

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Authors:  H J Evans
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Journal:  Oncotarget       Date:  2017-10-26

6.  Mutation of SPINOPHILIN (PPP1R9B) found in human tumors promotes the tumorigenic and stemness properties of cells.

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Review 7.  Role of the Holoenzyme PP1-SPN in the Dephosphorylation of the RB Family of Tumor Suppressors During Cell Cycle.

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  7 in total

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