Literature DB >> 8460637

THRA1 and D17S183 flank an interval of < 4 cM for the breast-ovarian cancer gene (BRCA1) on chromosome 17q21.

A M Bowcock1, L A Anderson, L S Friedman, D M Black, S Osborne-Lawrence, S E Rowell, J M Hall, E Solomon, M C King.   

Abstract

In order to pinpoint the locale of the gene for early-onset familial breast and ovarian cancer (BRCA1), polymorphisms were developed within the locus for thyroid hormone receptor alpha (THRA1) and for several anonymous sequences at chromosome 17q12-q21. The THRA1 polymorphism is a dinucleotide repeat with 10 alleles and heterozygosity.79. Gene mapping in extended families with inherited, early-onset breast and ovarian cancer indicates that BRCA1 is distal to THRA1 and proximal to D17S183 (SCG43), an interval of < 4 cM. This locale excludes HER2, THRA1, WNT3, HOX2, NGFR, PHB, COLIA1, NME1, and NME2 as candidates for BRCA1 but does not exclude RARA or EDH17B. Resolving the remaining recombination events in these families by new polymorphisms in the THRA1-D17S183 interval will facilitate positional cloning of the breast-ovarian cancer gene on chromosome 17q12-q21.

Entities:  

Mesh：

Substances：

Year:  1993        PMID： 8460637      PMCID： PMC1682071     

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN： 0002-9297            Impact factor:   11.025


  14 in total

1.  Dinucleotide repeat polymorphism at the D17S518 locus.

Authors:  F J Couch; T V McCarthy; R G Gregg; K Hogan
Journal:  Nucleic Acids Res       Date:  1991-09-25       Impact factor: 16.971

2.  Dinucleotide repeat polymorphisms at the D17S250 and D17S261 loci.

Authors:  J L Weber; A E Kwitek; P E May; M R Wallace; F S Collins; D H Ledbetter
Journal:  Nucleic Acids Res       Date:  1990-08-11       Impact factor: 16.971

3.  Closing in on a breast cancer gene on chromosome 17q.

Authors:  J M Hall; L Friedman; C Guenther; M K Lee; J L Weber; D M Black; M C King
Journal:  Am J Hum Genet       Date:  1992-06       Impact factor: 11.025

4.  G to A polymorphism at amino acid codon 655 of the human erbB-2/HER2 gene.

Authors:  J Papewalis; M F Rajewsky
Journal:  Nucleic Acids Res       Date:  1991-10-11       Impact factor: 16.971

5.  Familial breast-ovarian cancer locus on chromosome 17q12-q23.

Authors:  S A Narod; J Feunteun; H T Lynch; P Watson; T Conway; J Lynch; G M Lenoir
Journal:  Lancet       Date:  1991-07-13       Impact factor: 79.321

6.  PCR detection of an MboI polymorphism in the ERBB2 (HER2; NEU) gene on chromosome 17q11.2-q12.

Authors:  J M Hall; M C King
Journal:  Nucleic Acids Res       Date:  1991-05-11       Impact factor: 16.971

7.  Cloning and characterization of the t(15;17) translocation breakpoint region in acute promyelocytic leukemia.

Authors:  R S Lemons; D Eilender; R A Waldmann; M Rebentisch; A K Frej; D H Ledbetter; C Willman; T McConnell; P O'Connell
Journal:  Genes Chromosomes Cancer       Date:  1990-07       Impact factor: 5.006

8.  Linkage of early-onset familial breast cancer to chromosome 17q21.

Authors:  J M Hall; M K Lee; B Newman; J E Morrow; L A Anderson; B Huey; M C King
Journal:  Science       Date:  1990-12-21       Impact factor: 47.728

9.  BRCA1 maps proximal to D17S579 on chromosome 17q21 by genetic analysis.

Authors:  J S Chamberlain; M Boehnke; T S Frank; S Kiousis; J Xu; S W Guo; E R Hauser; R A Norum; E A Helmbold; D S Markel
Journal:  Am J Hum Genet       Date:  1993-04       Impact factor: 11.025

10.  Genomic organization of the human thyroid hormone receptor alpha (c-erbA-1) gene.

Authors:  V Laudet; A Begue; C Henry-Duthoit; A Joubel; P Martin; D Stehelin; S Saule
Journal:  Nucleic Acids Res       Date:  1991-03-11       Impact factor: 16.971
View more
  25 in total

1.  Biological indices in the assessment of breast cancer.

Authors:  A S Leong; A K Lee
Journal:  Clin Mol Pathol       Date:  1995-10

2.  The human breast and the ancestral reproductive cycle : A preliminary inquiry into breast cancer etiology.

Authors:  K Coe; L B Steadman
Journal:  Hum Nat       Date:  1995-09

3.  Evidence for genetic anticipation in non-Mendelian diseases.

Authors:  A D Paterson; J L Kennedy; A Petronis
Journal:  Am J Hum Genet       Date:  1996-07       Impact factor: 11.025

4.  A TGFβ-miR-182-BRCA1 axis controls the mammary differentiation hierarchy.

Authors:  Haydeliz Martinez-Ruiz; Irineu Illa-Bochaca; Coral Omene; Douglas Hanniford; Qi Liu; Eva Hernando; Mary Helen Barcellos-Hoff
Journal:  Sci Signal       Date:  2016-12-06       Impact factor: 8.192

5.  UGT1A1*6, UGT1A7*3 and UGT1A9*1b polymorphisms are predictive markers for severe toxicity in patients with metastatic gastrointestinal cancer treated with irinotecan-based regimens.

Authors:  Chengxu Cui; Chang Shu; Dandan Cao; Yi Yang; Junbao Liu; Shuping Shi; Zhujun Shao; Nan Wang; Ting Yang; Hao Liang; Shanshan Zou; Songnian Hu
Journal:  Oncol Lett       Date:  2016-09-14       Impact factor: 2.967

Review 6.  Hereditary breast cancer and family cancer syndromes.

Authors:  H T Lynch; J Lynch; T Conway; P Watson; J Feunteun; G Lenoir; S Narod; R Fitzgibbons
Journal:  World J Surg       Date:  1994 Jan-Feb       Impact factor: 3.352

Review 7.  Molecular cloning of BRCA1: a gene for early onset familial breast and ovarian cancer.

Authors:  A M Bowcock
Journal:  Breast Cancer Res Treat       Date:  1993-11       Impact factor: 4.872

8.  Further evidence of a relationship between the retinoic acid receptor alpha locus and nonsyndromic cleft lip with or without cleft palate (CL +/- P)

Authors:  D Shaw; A Ray; M Marazita; L Field
Journal:  Am J Hum Genet       Date:  1993-11       Impact factor: 11.025

9.  BRCA1 maps proximal to D17S579 on chromosome 17q21 by genetic analysis.

Authors:  J S Chamberlain; M Boehnke; T S Frank; S Kiousis; J Xu; S W Guo; E R Hauser; R A Norum; E A Helmbold; D S Markel
Journal:  Am J Hum Genet       Date:  1993-04       Impact factor: 11.025

10.  Genetic linkage analysis in familial breast and ovarian cancer: results from 214 families. The Breast Cancer Linkage Consortium.

Authors:  D F Easton; D T Bishop; D Ford; G P Crockford
Journal:  Am J Hum Genet       Date:  1993-04       Impact factor: 11.025
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.