Literature DB >> 8460503

Expression of the La Crosse M segment proteins in a recombinant vaccinia expression system mediates pH-dependent cellular fusion.

D R Jacoby1, C Cooke, I Prabakaran, J Boland, N Nathanson, F Gonzalez-Scarano.   

Abstract

To study the expression of La Crosse virus (LAC) glycoproteins, G1 and G2, we constructed a cDNA copy of the open reading frame (ORF) of the middle RNA segment and expressed it in a recombinant vaccinia virus (VV.ORF). Cells infected with VV.ORF expressed G1 and G2 at the cell surface and formed syncytia with a pH profile similar to that of LAC. These experiments provide a system of studying the biological functions of the LAC glycoproteins, including processing, targeting, fusion, receptor binding, and antigenicity.

Entities:  

Mesh：

Substances：

Year:  1993        PMID： 8460503     DOI： 10.1006/viro.1993.1213

Source DB:  PubMed          Journal:  Virology        ISSN： 0042-6822            Impact factor:   3.616


  18 in total

1.  Comparative analysis of G1 glycoprotein-coding sequences of Cache Valley virus (Bunyaviridae: Bunyavirus) isolates.

Authors:  C L Brockus; P R Grimstad
Journal:  Virus Genes       Date:  2001-03       Impact factor: 2.332

2.  Mutagenesis of the La Crosse Virus glycoprotein supports a role for Gc (1066-1087) as the fusion peptide.

Authors:  Matthew L Plassmeyer; Samantha S Soldan; Karen M Stachelek; Susan M Roth; Julio Martín-García; Francisco González-Scarano
Journal:  Virology       Date:  2006-10-05       Impact factor: 3.616

3.  Protection from La Crosse virus encephalitis with recombinant glycoproteins: role of neutralizing anti-G1 antibodies.

Authors:  A Pekosz; C Griot; K Stillmock; N Nathanson; F Gonzalez-Scarano
Journal:  J Virol       Date:  1995-06       Impact factor: 5.103

4.  Polygenic control of neuroinvasiveness in California serogroup bunyaviruses.

Authors:  C Griot; A Pekosz; D Lukac; S S Scherer; K Stillmock; D Schmeidler; M J Endres; F Gonzalez-Scarano; N Nathanson
Journal:  J Virol       Date:  1993-07       Impact factor: 5.103

5.  Efficient cDNA-based rescue of La Crosse bunyaviruses expressing or lacking the nonstructural protein NSs.

Authors:  Gjon Blakqori; Friedemann Weber
Journal:  J Virol       Date:  2005-08       Impact factor: 5.103

6.  Functional analysis of N-linked glycosylation mutants of the measles virus fusion protein synthesized by recombinant vaccinia virus vectors.

Authors:  G Alkhatib; S H Shen; D Briedis; C Richardson; B Massie; R Weinberg; D Smith; J Taylor; E Paoletti; J Roder
Journal:  J Virol       Date:  1994-03       Impact factor: 5.103

7.  Inhibition of bunyaviruses, phleboviruses, and hantaviruses by human MxA protein.

Authors:  M Frese; G Kochs; H Feldmann; C Hertkorn; O Haller
Journal:  J Virol       Date:  1996-02       Impact factor: 5.103

8.  Prevalence and protein specificity of human antibodies to Inkoo virus infection.

Authors:  Niina Putkuri; Antti Vaheri; Olli Vapalahti
Journal:  Clin Vaccine Immunol       Date:  2007-10-17

9.  A duplex real-time reverse transcriptase polymerase chain reaction assay for the detection of California serogroup and Cache Valley viruses.

Authors:  Heng Wang; Seela Nattanmai; Laura D Kramer; Kristen A Bernard; Norma P Tavakoli
Journal:  Diagn Microbiol Infect Dis       Date:  2009-10       Impact factor: 2.803

10.  Functional analysis of the Bunyamwera orthobunyavirus Gc glycoprotein.

Authors:  Xiaohong Shi; Josthna Goli; Gordon Clark; Kristina Brauburger; Richard M Elliott
Journal:  J Gen Virol       Date:  2009-07-01       Impact factor: 3.891
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.