Literature DB >> 8460400

Mapping of the genes for human endoplasmic reticular heat shock protein gp96/grp94.

R G Maki1, R L Eddy, M Byers, T B Shows, P K Srivastava.   

Abstract

The murine tumor rejection antigen gp96 (TRA1, mapped to mouse chromosome 10) is a member of the heat shock protein family. Using a fragment of the murine gp96 cDNA as a probe, three gp96-related human genes have been isolated and structurally characterized. They have been mapped to human chromosomes 1 (p22), 12 (q24.2-->q24.3), and 15 (q25-->q26) by Southern blot hybridization and in situ hybridization of gene-specific probes. Only one of the genes, designated TRA1 (human chromosome 12) is a coding gene; the other genes (TRA1P1 and TRAP2) appear to be independently derived, processed pseudogenes.

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Year:  1993        PMID: 8460400     DOI: 10.1007/bf01233956

Source DB:  PubMed          Journal:  Somat Cell Mol Genet        ISSN: 0740-7750


  5 in total

1.  Rabbit cardiac and skeletal myocytes differ in constitutive and inducible expression of the glucose-regulated protein GRP94.

Authors:  M Vitadello; P Colpo; L Gorza
Journal:  Biochem J       Date:  1998-06-01       Impact factor: 3.857

2.  Endo-beta-D-glucuronidase (heparanase) activity of heat-shock protein/tumour rejection antigen gp96.

Authors:  P K Srivastava
Journal:  Biochem J       Date:  1994-08-01       Impact factor: 3.857

3.  Retroviral insertions in Evi12, a novel common virus integration site upstream of Tra1/Grp94, frequently coincide with insertions in the gene encoding the peripheral cannabinoid receptor Cnr2.

Authors:  P J Valk; Y Vankan; M Joosten; N A Jenkins; N G Copeland; B Löwenberg; R Delwel
Journal:  J Virol       Date:  1999-05       Impact factor: 5.103

4.  GRP94 is essential for mesoderm induction and muscle development because it regulates insulin-like growth factor secretion.

Authors:  Sherry Wanderling; Birgitte B Simen; Olga Ostrovsky; Noreen T Ahmed; Shawn M Vogen; Tali Gidalevitz; Yair Argon
Journal:  Mol Biol Cell       Date:  2007-07-18       Impact factor: 4.138

Review 5.  Therapeutic cancer vaccines: using unique antigens.

Authors:  Jonathan J Lewis
Journal:  Proc Natl Acad Sci U S A       Date:  2004-08-05       Impact factor: 11.205

  5 in total

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