H Klonoff-Cohen1, S Edelstein, D Savitz. 1. Division of Epidemiology, Community and Family Medicine, University of California, San Diego, La Jolla.
Abstract
OBJECTIVE: To examine the relationship between cigarette smoking during pregnancy and the development of preeclampsia. METHODS: A case-control study compared the smoking histories of 110 nulliparous preeclamptic women and 115 healthy nulliparas aged 15-35 years who delivered at North Carolina Memorial Hospital. RESULTS: Unconditioned logistic regression relating smoking during pregnancy to preeclampsia yielded an odds ratio of 0.71 (95% confidence interval 0.33-1.50) when adjusting for working during pregnancy, alcohol use, medication use, contraceptive choices with the father of the index pregnancy, and family history of preeclampsia. There was no evidence of a dose-response effect of reduced risk for heavier smokers. CONCLUSIONS: Despite major methodologic improvements from previous studies, including rigorous diagnostic criteria for preeclampsia, a negative, non-statistically significant association persisted between cigarette smoking during pregnancy and preeclampsia, similar in magnitude to that of previous reports.
OBJECTIVE: To examine the relationship between cigarette smoking during pregnancy and the development of preeclampsia. METHODS: A case-control study compared the smoking histories of 110 nulliparous preeclamptic women and 115 healthy nulliparas aged 15-35 years who delivered at North Carolina Memorial Hospital. RESULTS: Unconditioned logistic regression relating smoking during pregnancy to preeclampsia yielded an odds ratio of 0.71 (95% confidence interval 0.33-1.50) when adjusting for working during pregnancy, alcohol use, medication use, contraceptive choices with the father of the index pregnancy, and family history of preeclampsia. There was no evidence of a dose-response effect of reduced risk for heavier smokers. CONCLUSIONS: Despite major methodologic improvements from previous studies, including rigorous diagnostic criteria for preeclampsia, a negative, non-statistically significant association persisted between cigarette smoking during pregnancy and preeclampsia, similar in magnitude to that of previous reports.
Authors: Thuridur A Gudnadóttir; Brian T Bateman; Sonia Hernádez-Díaz; Miguel Angel Luque-Fernandez; Unnur Valdimarsdottir; Helga Zoega Journal: PLoS One Date: 2016-03-24 Impact factor: 3.240
Authors: Ya-Yuan Fu; Jennifer C Nergard; Nicole K Barnette; Yan-Ling Wang; Karl X Chai; Li-Mei Chen Journal: PLoS One Date: 2012-08-17 Impact factor: 3.240