Literature DB >> 8459219

The life span of naive alpha/beta T cells in secondary lymphoid organs.

H von Boehmer1, K Hafen.   

Abstract

We have determined the life span of naive CD4-8+ T cells in T cell receptor transgenic mice. We find that such cells do not divide in secondary lymphoid organs in both normal euthymic mice and T cell-deficient mice. By both continuous labeling and by chasing pulse-labeled cells, we find that the minimum life span of the naive T cells is in the order of 8 wk.

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Year:  1993        PMID： 8459219      PMCID： PMC2190982          DOI： 10.1084/jem.177.4.891

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  23 in total

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  38 in total

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9.  Transgenic mice carrying the diphtheria toxin A chain gene under the control of the granzyme A promoter: expected depletion of cytotoxic cells and unexpected depletion of CD8 T cells.

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