Literature DB >> 8458908

High-performance liquid chromatographic determination of nicotine and its urinary metabolites via their 1,3-diethyl-2-thiobarbituric acid derivatives.

K Rustemeier1, D Demetriou, G Schepers, P Voncken.   

Abstract

The 1,3-diethyl-2-thiobarbituric acid (DETBA) assay for nicotine metabolites has been improved so that it can be used to determine the concentrations of nicotine and up to 12 metabolites in the urine of humans and laboratory animals, including phase 2 metabolites. The products of beta-glucuronidase cleavage found in human urine were mainly trans-3'-hydroxycotinine, cotinine, and a small amount of nicotine. Following isolation, spectroscopic analyses showed the structure of the nicotine DETBA derivative to be the one-to-one ring-opening product of DEBTA and the cyanopyridinium salt of nicotine.

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Year:  1993        PMID： 8458908     DOI： 10.1016/0378-4347(93)80201-e

Source DB:  PubMed          Journal:  J Chromatogr


  4 in total

1.  Metabolism of S-nicotine in noninduced and aroclor-induced rats.

Authors:  G Schepers; K Rustemeier; R A Walk; U Hackenberg
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1993 Apr-Jun       Impact factor: 2.441

2.  Assessment of inhalation toxicity of cigarette smoke and aerosols from flavor mixtures: 5-week study in A/J mice.

Authors:  Ee Tsin Wong; Karsta Luettich; Lydia Cammack; Chin Suan Chua; David Sciuscio; Celine Merg; Maica Corciulo; Romain Piault; Kumar Ashutosh; Cameron Smith; Patrice Leroy; Fabian Moine; Anneke Glabasnia; Pierrick Diana; Cecilia Chia; Ching Keong Tung; Nikolai Ivanov; Julia Hoeng; Manuel Peitsch; Kyeonghee Monica Lee; Patrick Vanscheeuwijck
Journal:  J Appl Toxicol       Date:  2022-06-08       Impact factor: 3.628

3.  Reduced toxicological activity of cigarette smoke by the addition of ammonia magnesium phosphate to the paper of an electrically heated cigarette: subchronic inhalation toxicology.

Authors:  O Moennikes; P M Vanscheeuwijck; B Friedrichs; E Anskeit; G J Patskan
Journal:  Inhal Toxicol       Date:  2008-05       Impact factor: 2.724

4.  Comprehensive systems biology analysis of a 7-month cigarette smoke inhalation study in C57BL/6 mice.

Authors:  Sam Ansari; Karine Baumer; Stéphanie Boué; Sophie Dijon; Remi Dulize; Kim Ekroos; Ashraf Elamin; Clement Foong; Emmanuel Guedj; Julia Hoeng; Nikolai V Ivanov; Subash Krishnan; Patrice Leroy; Florian Martin; Celine Merg; Michael J Peck; Manuel C Peitsch; Blaine Phillips; Walter K Schlage; Thomas Schneider; Marja Talikka; Bjoern Titz; Patrick Vanscheeuwijck; Emilija Veljkovic; Terhi Vihervaara; Gregory Vuillaume; Ching Qing Woon
Journal:  Sci Data       Date:  2016-01-05       Impact factor: 6.444
  4 in total

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