| Literature DB >> 8458717 |
T G Terrell1, P K Working, C P Chow, J D Green.
Abstract
The systemic administration of high doses of rHuTGF-beta 1 to rats produced a spectrum of lesions in multiple target tissues, including liver, bone, kidney, heart, thymus, pancreas, stomach, cecum, at the injection vein, and in skeletal muscle at the site of anesthetic injection. The majority of these lesions can be attributed to known biological activities of TGF-beta 1. High-dose dermal application resulted in local effects at the wound sites without systemic toxicity.Entities:
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Year: 1993 PMID： 8458717 DOI： 10.1016/b978-0-12-364935-5.50009-2
Source DB: PubMed Journal: Int Rev Exp Pathol ISSN： 0074-7718