| Literature DB >> 8458687 |
A F el-Waer1, T Benson, K T Douglas.
Abstract
The synthesis and chemical characterisation of a range of substrate analogues for trypanothione reductase are described, with the spermidine portion of trypanothione replaced by the 3-dimethylaminopropylamide moiety. Using 1-hydroxybenzotriazole/N-hydroxysuccinimide coupling, products were obtained which had a range of replacements of the gamma-glutamyl groups of the enzyme substrate. The materials were characterised by FPLC, 1H/13C NMR spectroscopy and FAB mass spectroscopy.Entities:
Mesh：
Substances：
Year: 1993 PMID： 8458687 DOI： 10.1111/j.1399-3011.1993.tb00124.x
Source DB: PubMed Journal: Int J Pept Protein Res ISSN： 0367-8377