Literature DB >> 8458532

Characterization of a third simple tandem repeat polymorphism in the human glucokinase gene.

M Stoffel1, G I Bell.   

Abstract

Recent studies have implicated mutations in the glucokinase gene as a cause of early-onset Type 2 (non-insulin-dependent) diabetes mellitus. Two simple tandem repeat DNA polymorphisms have been identified in this gene and used for genetic studies. However, their heterozygosity is relatively low and not all families are informative for linkage with these markers. Here we report the characterization of a third simple tandem repeat polymorphism that can be used for genetic studies.

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Year:  1993        PMID： 8458532     DOI： 10.1007/bf00400700

Source DB:  PubMed          Journal:  Diabetologia        ISSN： 0012-186X            Impact factor:   10.122


  8 in total

1.  Nonsense mutation in the glucokinase gene causes early-onset non-insulin-dependent diabetes mellitus.

Authors:  N Vionnet; M Stoffel; J Takeda; K Yasuda; G I Bell; H Zouali; S Lesage; G Velho; F Iris; P Passa
Journal:  Nature       Date:  1992-04-23       Impact factor: 49.962

2.  Close linkage of glucokinase locus on chromosome 7p to early-onset non-insulin-dependent diabetes mellitus.

Authors:  P Froguel; M Vaxillaire; F Sun; G Velho; H Zouali; M O Butel; S Lesage; N Vionnet; K Clément; F Fougerousse
Journal:  Nature       Date:  1992-03-12       Impact factor: 49.962

3.  Linkage of type 2 diabetes to the glucokinase gene.

Authors:  A T Hattersley; R C Turner; M A Permutt; P Patel; Y Tanizawa; K C Chiu; S O'Rahilly; P J Watkins; J S Wainscoat
Journal:  Lancet       Date:  1992-05-30       Impact factor: 79.321

4.  Gene for non-insulin-dependent diabetes mellitus (maturity-onset diabetes of the young subtype) is linked to DNA polymorphism on human chromosome 20q.

Authors:  G I Bell; K S Xiang; M V Newman; S H Wu; L G Wright; S S Fajans; R S Spielman; N J Cox
Journal:  Proc Natl Acad Sci U S A       Date:  1991-02-15       Impact factor: 11.205

5.  Missense glucokinase mutation in maturity-onset diabetes of the young and mutation screening in late-onset diabetes.

Authors:  M Stoffel; P Patel; Y M Lo; A T Hattersley; A M Lucassen; R Page; J I Bell; G I Bell; R C Turner; J S Wainscoat
Journal:  Nat Genet       Date:  1992-10       Impact factor: 38.330

6.  Human pancreatic beta-cell glucokinase: cDNA sequence and localization of the polymorphic gene to chromosome 7, band p 13.

Authors:  S Nishi; M Stoffel; K Xiang; T B Shows; G I Bell; J Takeda
Journal:  Diabetologia       Date:  1992-08       Impact factor: 10.122

7.  Human glucokinase gene: isolation, characterization, and identification of two missense mutations linked to early-onset non-insulin-dependent (type 2) diabetes mellitus.

Authors:  M Stoffel; P Froguel; J Takeda; H Zouali; N Vionnet; S Nishi; I T Weber; R W Harrison; S J Pilkis; S Lesage
Journal:  Proc Natl Acad Sci U S A       Date:  1992-08-15       Impact factor: 11.205

8.  A polymorphic (CA)n repeat element maps the human glucokinase gene (GCK) to chromosome 7p.

Authors:  A Matsutani; R Janssen; H Donis-Keller; M A Permutt
Journal:  Genomics       Date:  1992-02       Impact factor: 5.736
  8 in total

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