Literature DB >> 8458385

Rat intestinal epithelial cell line IEC-6 is activated by recombinant interferon-gamma to inhibit replication of the coccidian Toxoplasma gondii.

I H Dimier1, D T Bout.   

Abstract

Toxoplasma gondii tachyzoites invaded and replicated in cultured rat small intestine cells of the line IEC-6. Treatment of rat small intestine cells with murine recombinant interferon-gamma resulted in a dose-dependent inhibition of intracellular T. gondii replication. This could be of relevance as a first line defense against Toxoplasma infection.

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Year:  1993        PMID： 8458385     DOI： 10.1002/eji.1830230435

Source DB:  PubMed          Journal:  Eur J Immunol        ISSN： 0014-2980            Impact factor:   5.532


  7 in total

1.  Toxoplasma gondii: changes of transepithelial ion transport in infected HT29/B6 cell monolayers.

Authors:  Sabine Kowalik; W Clauss; H Zahner
Journal:  Parasitol Res       Date:  2003-12-09       Impact factor: 2.289

2.  Immunity to Cryptosporidium muris infection in mice is expressed through gut CD4+ intraepithelial lymphocytes.

Authors:  V McDonald; H A Robinson; J P Kelly; G J Bancroft
Journal:  Infect Immun       Date:  1996-07       Impact factor: 3.441

3.  IL-15 converts human intestinal intraepithelial lymphocytes to CD94 producers of IFN-gamma and IL-10, the latter promoting Fas ligand-mediated cytotoxicity.

Authors:  Ellen C Ebert
Journal:  Immunology       Date:  2005-05       Impact factor: 7.397

4.  Giardia induces proliferation and interferon gamma production by intestinal lymphocytes.

Authors:  E C Ebert
Journal:  Gut       Date:  1999-03       Impact factor: 23.059

5.  CD40 induces anti-Toxoplasma gondii activity in nonhematopoietic cells dependent on autophagy proteins.

Authors:  Jennifer Van Grol; Luis Muniz-Feliciano; Jose-Andres C Portillo; Vera L Bonilha; Carlos S Subauste
Journal:  Infect Immun       Date:  2013-03-18       Impact factor: 3.441

6.  Murine dendritic cells pulsed in vitro with Toxoplasma gondii antigens induce protective immunity in vivo.

Authors:  I Bourguin; M Moser; D Buzoni-Gatel; F Tielemans; D Bout; J Urbain; O Leo
Journal:  Infect Immun       Date:  1998-10       Impact factor: 3.441

7.  Interferon-gamma-activated primary enterocytes inhibit Toxoplasma gondii replication: a role for intracellular iron.

Authors:  I H Dimier; D T Bout
Journal:  Immunology       Date:  1998-08       Impact factor: 7.397
  7 in total

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