Literature DB >> 8456624

Does TGF-beta protect articular cartilage in vivo?

H M van Beuningen1, P M van der Kraan, O J Arntz, W B van den Berg.   

Abstract

Repeated intraarticular injections of transforming growth factor beta cause stimulation of articular cartilage proteoglycan synthesis, influx of inflammatory cells, fibrosis and osteophyte formation. When injected together with interleukin-1, TGF-beta enhances IL-1 induced cell-attraction in a synergistic way, while it counteracts IL-1 induced suppression of cartilage PG synthesis.

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Year:  1993        PMID： 8456624     DOI： 10.1007/978-3-0348-7442-7_14

Source DB:  PubMed          Journal:  Agents Actions Suppl        ISSN： 0379-0363


  3 in total

1.  Expression of transforming growth factor-beta (TGFbeta) and the TGFbeta signalling molecule SMAD-2P in spontaneous and instability-induced osteoarthritis: role in cartilage degradation, chondrogenesis and osteophyte formation.

Authors:  E N Blaney Davidson; E L Vitters; P M van der Kraan; W B van den Berg
Journal:  Ann Rheum Dis       Date:  2006-01-26       Impact factor: 19.103

2.  Histomorphometric Evaluation of Cartilage Degradation using Rabbit Articular Chondrocytes Cultured in Alginate Beads - Effects of Hyaluronan.

Authors:  K Nakatsuka; K Kurita; Taro Hayakawa; Katsuhito Nakashima; Kyoko Yamashita; Takeshi Hoshino; Kyosuke Miyazaki
Journal:  Int J Biomed Sci       Date:  2010-06

3.  Characterization of osteoarthritic human knees indicates potential sex differences.

Authors:  Qingfen Pan; Mary I O'Connor; Richard D Coutts; Sharon L Hyzy; Rene Olivares-Navarrete; Zvi Schwartz; Barbara D Boyan
Journal:  Biol Sex Differ       Date:  2016-06-02       Impact factor: 5.027
  3 in total

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