Literature DB >> 8456283

Betacellulin: a mitogen from pancreatic beta cell tumors.

Y Shing1, G Christofori, D Hanahan, Y Ono, R Sasada, K Igarashi, J Folkman.   

Abstract

Betacellulin, a member of the epidermal growth factor family, has been identified in the conditioned medium of cell lines derived from mouse pancreatic beta cell tumors. Betacellulin is a 32-kilodalton glycoprotein that appears to be processed from a larger transmembrane precursor by proteolytic cleavage. The carboxyl-terminal domain of betacellulin has 50 percent sequence similarity with that of rat transforming growth factor alpha. Betacellulin is a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.

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Year:  1993        PMID： 8456283     DOI： 10.1126/science.8456283

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  79 in total

1.  Receptor-based antidote for diphtheria.

Authors:  Jeong-Heon Cha; Joanna S Brooke; Mee Young Chang; Leon Eidels
Journal:  Infect Immun       Date:  2002-05       Impact factor: 3.441

2.  Neuregulin-3 (NRG3): a novel neural tissue-enriched protein that binds and activates ErbB4.

Authors:  D Zhang; M X Sliwkowski; M Mark; G Frantz; R Akita; Y Sun; K Hillan; C Crowley; J Brush; P J Godowski
Journal:  Proc Natl Acad Sci U S A       Date:  1997-09-02       Impact factor: 11.205

3.  The heparin-binding domain of HB-EGF mediates localization to sites of cell-cell contact and prevents HB-EGF proteolytic release.

Authors:  Robin N Prince; Eric R Schreiter; Peng Zou; H Steven Wiley; Alice Y Ting; Richard T Lee; Douglas A Lauffenburger
Journal:  J Cell Sci       Date:  2010-06-08       Impact factor: 5.285

4.  ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling.

Authors:  D Graus-Porta; R R Beerli; J M Daly; N E Hynes
Journal:  EMBO J       Date:  1997-04-01       Impact factor: 11.598

5.  Smooth Muscle Cell Abnormalities Associated with Gastric ECL Cell Carcinoids.

Authors:  Cesare Bordi; Pietro Caruana; Tiziana D'Adda; Cinzia Azzoni
Journal:  Endocr Pathol       Date:  1995       Impact factor: 3.943

6.  Phenotypic variation resulting from a deficiency of epidermal growth factor receptor in mice is caused by extensive genetic heterogeneity that can be genetically and molecularly partitioned.

Authors:  Karen E Strunk; Vicky Amann; David W Threadgill
Journal:  Genetics       Date:  2004-08       Impact factor: 4.562

7.  HIT cells secrete β-cell mitogenic factors.

Authors:  B Bréant; A Lieuvin; C Lavergne; J C Marie; G Rosselin
Journal:  Endocrine       Date:  1995-01       Impact factor: 3.633

8.  Epiregulin is a potent vascular smooth muscle cell-derived mitogen induced by angiotensin II, endothelin-1, and thrombin.

Authors:  D S Taylor; X Cheng; J E Pawlowski; A R Wallace; P Ferrer; C J Molloy
Journal:  Proc Natl Acad Sci U S A       Date:  1999-02-16       Impact factor: 11.205

Review 9.  Trafficking of epidermal growth factor receptor ligands in polarized epithelial cells.

Authors:  Bhuminder Singh; Robert J Coffey
Journal:  Annu Rev Physiol       Date:  2013-11-08       Impact factor: 19.318

10.  Altered EGFR localization and degradation in human breast cancer cells with an amphiregulin/EGFR autocrine loop.

Authors:  Nicole E Willmarth; Andrea Baillo; Michele L Dziubinski; Kristy Wilson; David J Riese; Stephen P Ethier
Journal:  Cell Signal       Date:  2008-10-14       Impact factor: 4.315
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