Literature DB >> 8456236

Effect of specific muscarinic M2 receptor antagonist on carbachol induced long-term REM sleep.

S Datta1, J J Quattrochi, J A Hobson.   

Abstract

Six cats were chronically implanted with a standard set of sleep-scoring electrodes and bilateral stainless-steel guide tubes for microinjection of drugs in the peribrachial area (PBL). Pretreatment of drug injection sites in the PBL with the M2 antagonist methoctramine blocks both the immediate triggering of ponto-geniculo-occipital (PGO) waves and the later prolonged enhancement of REM sleep that is induced by carbachol. These results support the hypothesis that the carbachol effects are mediated via the M2 muscarinic receptor that is known to be present in the PBL.

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Year:  1993        PMID： 8456236

Source DB:  PubMed          Journal:  Sleep        ISSN： 0161-8105            Impact factor:   5.849


  7 in total

Review 1.  Neurobiological mechanisms for the regulation of mammalian sleep-wake behavior: reinterpretation of historical evidence and inclusion of contemporary cellular and molecular evidence.

Authors:  Subimal Datta; Robert Ross Maclean
Journal:  Neurosci Biobehav Rev       Date:  2007-03-12       Impact factor: 8.989

Review 2.  Cellular basis of pontine ponto-geniculo-occipital wave generation and modulation.

Authors:  S Datta
Journal:  Cell Mol Neurobiol       Date:  1997-06       Impact factor: 5.046

Review 3.  Control of sleep and wakefulness.

Authors:  Ritchie E Brown; Radhika Basheer; James T McKenna; Robert E Strecker; Robert W McCarley
Journal:  Physiol Rev       Date:  2012-07       Impact factor: 37.312

4.  Electrophysiological characterization of neurons in the dorsolateral pontine rapid-eye-movement sleep induction zone of the rat: Intrinsic membrane properties and responses to carbachol and orexins.

Authors:  R E Brown; S Winston; R Basheer; M M Thakkar; R W McCarley
Journal:  Neuroscience       Date:  2006-09-26       Impact factor: 3.590

5.  Endogenous GABA levels in the pontine reticular formation are greater during wakefulness than during rapid eye movement sleep.

Authors:  Giancarlo Vanini; Bradley L Wathen; Ralph Lydic; Helen A Baghdoyan
Journal:  J Neurosci       Date:  2011-02-16       Impact factor: 6.167

6.  Neuropharmacological characterization of basal forebrain cholinergic stimulated cataplexy in narcoleptic canines.

Authors:  M S Reid; S Nishino; M Tafti; J M Siegel; W C Dement; E Mignot
Journal:  Exp Neurol       Date:  1998-05       Impact factor: 5.330

7.  The Transition Between Slow-Wave Sleep and REM Sleep Constitutes an Independent Sleep Stage Organized by Cholinergic Mechanisms in the Rostrodorsal Pontine Tegmentum.

Authors:  Carlos Carrera-Cañas; Miguel Garzón; Isabel de Andrés
Journal:  Front Neurosci       Date:  2019-07-23       Impact factor: 4.677
  7 in total

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