Literature DB >> 84560

Akaline phosphatase: activity and variation in human diploid fibroblasts.

F J Vanneuville, J G Leroy, A F Van Elsen.   

Abstract

A method is introduced for the assay of alkaline phosphatase in homogenates of cultured human skin fibroblasts. In a first group of 11 strains, a four- to fifteen-fold increase of enzyme activity is consistently observed following a period of starvation. In the remaining 31 cell-strains similar specific activities of alkaline phosphatase are found irrespective of medium changes. In regularly fed cultures, an inverse exponential correlation between the specific activity of alkaline phosphatase and the age of the donor has been detected.

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Year:  1978        PMID： 84560     DOI： 10.3109/13813457809069534

Source DB:  PubMed          Journal:  Arch Int Physiol Biochim        ISSN： 0003-9799


  2 in total

1.  Infantile hypophosphatasia: enzymatic defect explored with alkaline phosphatase-deficient skin fibroblasts in culture.

Authors:  M P Whyte; S D Rettinger; L A Vrabel
Journal:  Calcif Tissue Int       Date:  1987-05       Impact factor: 4.333

2.  Analysis of liver/bone/kidney alkaline phosphatase mRNA, DNA, and enzymatic activity in cultured skin fibroblasts from 14 unrelated patients with severe hypophosphatasia.

Authors:  M J Weiss; K Ray; M D Fallon; M P Whyte; K N Fedde; M A Lafferty; R A Mulivor; H Harris
Journal:  Am J Hum Genet       Date:  1989-05       Impact factor: 11.025
  2 in total

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