Literature DB >> 8452523

Effect of heterologous expression of acyl-CoA-binding protein on acyl-CoA level and composition in yeast.

S Mandrup1, R Jepsen, H Skøtt, J Rosendal, P Højrup, K Kristiansen, J Knudsen.   

Abstract

We have expressed a bovine synthetic acyl-CoA-binding protein (ACBP) gene in yeast (Saccharomyces cerevisiae) under the control of the GAL1 promoter. The heterologously expressed bovine ACBP constituted up to 6.4% of total cellular protein and the processing was identical with that of native bovine ACBP, i.e. the initiating methionine was removed and the following serine residue was N-acetylated. The expression of this protein did not affect the growth rate of the cells. Determination of the yeast acyl-CoA pool size showed a close positive correlation between the ACBP content of the cells and the size of the acyl-CoA pool. Thus ACBP can act as an intracellular acyl-CoA pool former. Possible physiological functions of ACBP in cells are discussed.

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Year:  1993        PMID： 8452523      PMCID： PMC1132282          DOI： 10.1042/bj2900369

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  41 in total

1.  Diazepam-binding inhibitor: a neuropeptide and/or an acyl-CoA ester binding protein?

Authors:  J Knudsen; M Nielsen
Journal:  Biochem J       Date:  1990-02-01       Impact factor: 3.857

2.  Messenger RNA degradation in Saccharomyces cerevisiae.

Authors:  A J Brown; I J Purvis; T C Santiago; A J Bettany; L Loughlin; J Moore
Journal:  Gene       Date:  1988-12-10       Impact factor: 3.688

3.  Fatty acyl-coenzyme A is required for budding of transport vesicles from Golgi cisternae.

Authors:  N Pfanner; L Orci; B S Glick; M Amherdt; S R Arden; V Malhotra; J E Rothman
Journal:  Cell       Date:  1989-10-06       Impact factor: 41.582

4.  The regulation of intracellular transport of cholesterol in bovine adrenal cells: purification of a novel protein.

Authors:  K Yanagibashi; Y Ohno; M Kawamura; P F Hall
Journal:  Endocrinology       Date:  1988-10       Impact factor: 4.736

5.  Putative diazepam binding inhibitor peptide: cDNA clones from rat.

Authors:  I Mocchetti; R Einstein; J Brosius
Journal:  Proc Natl Acad Sci U S A       Date:  1986-10       Impact factor: 11.205

6.  Cloning and expression of cDNA for human diazepam binding inhibitor, a natural ligand of an allosteric regulatory site of the gamma-aminobutyric acid type A receptor.

Authors:  P W Gray; D Glaister; P H Seeburg; A Guidotti; E Costa
Journal:  Proc Natl Acad Sci U S A       Date:  1986-10       Impact factor: 11.205

7.  Acyl-CoA-binding protein in the rat. Purification, binding characteristics, tissue concentrations and amino acid sequence.

Authors:  J Knudsen; P Højrup; H O Hansen; H F Hansen; P Roepstorff
Journal:  Biochem J       Date:  1989-09-01       Impact factor: 3.857

8.  Identification of des-(Gly-Ile)-endozepine as an effector of corticotropin-dependent adrenal steroidogenesis: stimulation of cholesterol delivery is mediated by the peripheral benzodiazepine receptor.

Authors:  M J Besman; K Yanagibashi; T D Lee; M Kawamura; P F Hall; J E Shively
Journal:  Proc Natl Acad Sci U S A       Date:  1989-07       Impact factor: 11.205

9.  Amino acid sequence of acyl-CoA-binding protein from cow liver.

Authors:  J Mikkelsen; P Højrup; P F Nielsen; P Roepstorff; J Knudsen
Journal:  Biochem J       Date:  1987-08-01       Impact factor: 3.857

10.  Comparison of the binding affinities of acyl-CoA-binding protein and fatty-acid-binding protein for long-chain acyl-CoA esters.

Authors:  J T Rasmussen; T Börchers; J Knudsen
Journal:  Biochem J       Date:  1990-02-01       Impact factor: 3.857
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  29 in total

1.  Analysis of coenzyme A activated compounds in actinomycetes.

Authors:  Matías Cabruja; Bernardo Bazet Lyonnet; Gustavo Millán; Hugo Gramajo; Gabriela Gago
Journal:  Appl Microbiol Biotechnol       Date:  2016-06-06       Impact factor: 4.813

Review 2.  Role of long-chain fatty acyl-CoA esters in the regulation of metabolism and in cell signalling.

Authors:  N J Faergeman; J Knudsen
Journal:  Biochem J       Date:  1997-04-01       Impact factor: 3.857

3.  Host acyl coenzyme A binding protein regulates replication complex assembly and activity of a positive-strand RNA virus.

Authors:  Jiantao Zhang; Arturo Diaz; Lan Mao; Paul Ahlquist; Xiaofeng Wang
Journal:  J Virol       Date:  2012-02-15       Impact factor: 5.103

4.  Compromised epidermal barrier stimulates Harderian gland activity and hypertrophy in ACBP-/- mice.

Authors:  Signe Bek; Ditte Neess; Karen Dixen; Maria Bloksgaard; Ann-Britt Marcher; John Chemnitz; Nils J Færgeman; Susanne Mandrup
Journal:  J Lipid Res       Date:  2015-07-04       Impact factor: 5.922

Review 5.  Acyl-CoA binding proteins: multiplicity and function.

Authors:  R E Gossett; A A Frolov; J B Roths; W D Behnke; A B Kier; F Schroeder
Journal:  Lipids       Date:  1996-09       Impact factor: 1.880

6.  Detection of acyl-CoA-binding protein in human red blood cells and investigation of its role in membrane phospholipid renewal.

Authors:  H Fyrst; J Knudsen; M A Schott; B H Lubin; F A Kuypers
Journal:  Biochem J       Date:  1995-03-15       Impact factor: 3.857

7.  Acyl-CoA-binding protein (ACBP) can mediate intermembrane acyl-CoA transport and donate acyl-CoA for beta-oxidation and glycerolipid synthesis.

Authors:  J T Rasmussen; N J Faergeman; K Kristiansen; J Knudsen
Journal:  Biochem J       Date:  1994-04-01       Impact factor: 3.857

Review 8.  The function of acyl-CoA-binding protein (ACBP)/diazepam binding inhibitor (DBI).

Authors:  J Knudsen; S Mandrup; J T Rasmussen; P H Andreasen; F Poulsen; K Kristiansen
Journal:  Mol Cell Biochem       Date:  1993 Jun 9-23       Impact factor: 3.396

9.  Yeast acyl-CoA-binding protein: acyl-CoA-binding affinity and effect on intracellular acyl-CoA pool size.

Authors:  J Knudsen; N J Faergeman; H Skøtt; R Hummel; C Børsting; T M Rose; J S Andersen; P Højrup; P Roepstorff; K Kristiansen
Journal:  Biochem J       Date:  1994-09-01       Impact factor: 3.857

10.  Transcriptional regulation of phospholipid biosynthesis is linked to fatty acid metabolism by an acyl-CoA-binding-protein-dependent mechanism in Saccharomyces cerevisiae.

Authors:  Søren Feddersen; Thomas B F Neergaard; Jens Knudsen; Nils J Faergeman
Journal:  Biochem J       Date:  2007-10-15       Impact factor: 3.857
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