Literature DB >> 8452205

Molecular mechanism of ethanol metabolism by human brain to fatty acid ethyl esters.

P S Bora1, L G Lange.   

Abstract

Ethanol metabolism in the human brain has been documented to occur with the formation of fatty acid ethyl esters. These neutral lipids can disorder membranes and interrupt mitochondrial function. Their formation is under the control of three synthases, localized to grey matter and purified to homogeneity. cDNA cloning demonstrates two of these enzymes to be GSH S-transferases and has enabled initiation of genetic studies of alcohol-induced CNS injury.

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Year:  1993        PMID： 8452205     DOI： 10.1111/j.1530-0277.1993.tb00721.x

Source DB:  PubMed          Journal:  Alcohol Clin Exp Res        ISSN： 0145-6008            Impact factor:   3.455


  6 in total

1.  Fatty acid ethyl esters in meconium: are they biomarkers of fetal alcohol exposure and effect?

Authors:  Enrique M Ostrea; Joel D Hernandez; Dawn M Bielawski; Jack M Kan; Gregorio M Leonardo; Michelle Buda Abela; Michael W Church; John H Hannigan; James J Janisse; Joel W Ager; Robert J Sokol
Journal:  Alcohol Clin Exp Res       Date:  2006-07       Impact factor: 3.455

Review 2.  Clinical and pathological features of alcohol-related brain damage.

Authors:  Natalie M Zahr; Kimberley L Kaufman; Clive G Harper
Journal:  Nat Rev Neurol       Date:  2011-04-12       Impact factor: 42.937

3.  Mutagenesis and characterization of specific residues in fatty acid ethyl ester synthase: a gene for alcohol-induced cardiomyopathy.

Authors:  P S Bora; D D Miller; B R Chaitman
Journal:  Mol Cell Biochem       Date:  1998-03       Impact factor: 3.396

4.  Effects of chronic ethanol consumption on brain synaptosomes and protective role of betaine.

Authors:  Gungor Kanbak; Okan Can Arslan; Ali Dokumacioglu; Kazim Kartkaya; Mine Erden Inal
Journal:  Neurochem Res       Date:  2007-09-01       Impact factor: 3.996

5.  Carnosine supplementation protects rat brain tissue against ethanol-induced oxidative stress.

Authors:  Ummuhani Ozel Turkcu; Ayşe Bilgihan; Gursel Biberoglu; Oznur Mertoglu Caglar
Journal:  Mol Cell Biochem       Date:  2010-01-03       Impact factor: 3.396

6.  Effect of boric acid on oxidative stress in rats with fetal alcohol syndrome.

Authors:  Ibrahim Sogut; Aysegul Oglakci; Kazim Kartkaya; Kevser Kusat Ol; Melis Savasan Sogut; Gungor Kanbak; Mine Erden Inal
Journal:  Exp Ther Med       Date:  2014-12-30       Impact factor: 2.447
  6 in total

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