Literature DB >> 8452107

Piritrexim-induced pulmonary toxicity.

R de Wit1, J Verweij, R Slingerland, G Stoter.   

Abstract

We describe a patient with transitional cell carcinoma of the renal pelvis who developed respiratory dysfunction and an abnormal chest x-ray with diffuse interstitial opacities while on chemotherapy with piritrexim, a methotrexate analog. Drug discontinuation resulted in complete resolution of the clinical and radiographic picture. The pulmonary toxicity is probably induced by piritrexim.

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Year:  1993        PMID: 8452107     DOI: 10.1097/00000421-199304000-00013

Source DB:  PubMed          Journal:  Am J Clin Oncol        ISSN: 0277-3732            Impact factor:   2.339


  1 in total

1.  A phase II study of oral piritrexim in recurrent high-grade (III, IV) glioma.

Authors:  N M Bleehen; H V Newman; R P Rampling; J R Ramsay; J T Roberts; P Bedford; A B Nethersell
Journal:  Br J Cancer       Date:  1995-09       Impact factor: 7.640

  1 in total

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