| Literature DB >> 8450318 |
L Z Lin1, H L Shieh, C K Angerhofer, J M Pezzuto, G A Cordell, L Xue, M E Johnson, N Ruangrungsi.
Abstract
An alkaloid extract derived from the roots of Cyclea barbata demonstrated cytotoxic and antimalarial activities, and five bisbenzylisoquinoline alkaloids, (+)-tetrandrine [1], (-)-limacine [2], (+)-thalrugosine [3], (+)-homoaromoline [4], and (-)-cycleapeltine [5], were isolated as the active principles. The complete and unambiguous assignments of the 1H- and 13C-nmr data of these substances were made by 1D and 2D nmr techniques (COSY, phase-sensitive ROESY, HETCOR, and FLOCK).Entities:
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Year: 1993 PMID： 8450318 DOI： 10.1021/np50091a004
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050