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Literature DB >> 8449972

Radioprotective effect of N-acetylcysteine on granulocyte/macrophage colony-forming cells of human bone marrow.

Abstract

N-Acetylcysteine, known as a radical scavenger, was examined for its influence on the radiotolerance of progenitor cells of granulocytopoiesis. Added before and after irradiation in a dose of 2 mg/ml to suspension cultures of non-adherent low-density human bone marrow cells N-acetylcysteine (AcCys) clearly improved the survival. The D0 value of the survival curve for granulocyte/macrophage colony-forming cells increased by a factor of 1.56 as compared to non-treated control suspensions. The improvement of radiation tolerance is probably not only based on the radical scavenger properties (radioprotective component) of AcCys, but also on the support of repair processes.

Entities: Chemical Species

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Year: 1993 PMID： 8449972 DOI： 10.1007/bf01208843

Source DB: PubMed Journal: J Cancer Res Clin Oncol ISSN： 0171-5216 Impact factor: 4.553

13 in total

1. Relationship of colony-stimulating activity to apparent kill of human colony-forming cells by irradiation and hydroxyurea.

Authors: H E Broxmeyer; P R Galbraith; F L Baker
Journal: Blood Date: 1976-03 Impact factor: 22.113

2. Protection of mouse bone marrow by WR-2721 after fractionated irradiation.

Authors: E L Travis; M Z Fang; I Basic
Journal: Int J Radiat Oncol Biol Phys Date: 1988-08 Impact factor: 7.038

3. Comparative behavioral toxicity of four sulfhydryl radioprotective compounds in mice: WR-2721, cysteamine, diethyldithiocarbamate, and N-acetylcysteine.

Authors: M R Landauer; H D Davis; J A Dominitz; J F Weiss
Journal: Pharmacol Ther Date: 1988 Impact factor: 12.310

1. Differences in quantification of DNA double-strand breaks assessed by 53BP1/γH2AX focus formation assays and the comet assay in mammalian cells treated with irradiation and N-acetyl-L-cysteine.

Authors: Tomomi Kurashige; Mika Shimamura; Yuji Nagayama
Journal: J Radiat Res Date: 2016-03-06 Impact factor: 2.724

1 in total

Radioprotective effect of N-acetylcysteine on granulocyte/macrophage colony-forming cells of human bone marrow.

1. Relationship of colony-stimulating activity to apparent kill of human colony-forming cells by irradiation and hydroxyurea.

2. Protection of mouse bone marrow by WR-2721 after fractionated irradiation.

3. Comparative behavioral toxicity of four sulfhydryl radioprotective compounds in mice: WR-2721, cysteamine, diethyldithiocarbamate, and N-acetylcysteine.

4. Effect of N-acetylcysteine on plasma cysteine and glutathione following paracetamol administration.

5. The effect of N-acetylcysteine inhalation on the tolerance to thoracic radiation in mice.

6. The radioprotective effect of N-acetylcysteine in thorax irradiation of mice.

Review 7. Acetylcysteine: a drug that is much more than a mucokinetic.

8. Effects of N-acetylcysteine on human polymorphonuclear leukocytes.

9. Radioprotection of hematopoietic tissues in mice by indomethacin.

10. 2-Mercaptoethanol and n-acetylcysteine enhance T cell colony formation in AIDS and ARC.

1. Differences in quantification of DNA double-strand breaks assessed by 53BP1/γH2AX focus formation assays and the comet assay in mammalian cells treated with irradiation and N-acetyl-L-cysteine.