Literature DB >> 844983

Heterotransplantation of retinoblastoma into the athymic "nude" mouse.

B L Gallie, D M Albert, J J Wong, N Buyukmihci, C A Pullafito.   

Abstract

Fresh surgical specimens of retinoblastoma were successfully transplanted into the anterior chamber of the "nude" mouse (a homozygous mutant, nu/nu, with a severe defect in cellular immunity), filling the eyes but failing to grow subcutaneously. Retinoblastoma cells from an established cell line, Y-79,1 spread from the intraocular injection site to invade the orbit, optic nerve, and brain and formed large tumors when implanted subcutaneously. Tumor cells injected into the anterior chamber of immunologically normal litter-males (heterozygotes, nu/+) survived for varying periods in the anterior chamber but showed little growth.

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Year:  1977        PMID： 844983

Source DB:  PubMed          Journal:  Invest Ophthalmol Vis Sci        ISSN： 0146-0404            Impact factor:   4.799


  19 in total

1.  Metastatic and nonmetastatic models of retinoblastoma.

Authors:  P Chévez-Barrios; M Y Hurwitz; K Louie; K T Marcus; V N Holcombe; P Schafer; C E Aguilar-Cordova; R L Hurwitz
Journal:  Am J Pathol       Date:  2000-10       Impact factor: 4.307

2.  Laminin-induced retinoblastoma cell differentiation: possible involvement of a 100-kDa cell-surface laminin-binding protein.

Authors:  A Albini; D M Noonan; A Melchiori; G F Fassina; M Percario; S Gentleman; J Toffenetti; G J Chader
Journal:  Proc Natl Acad Sci U S A       Date:  1992-03-15       Impact factor: 11.205

3.  Evaluation of response to chemotherapy in retinoblastoma heterotransplanted to the eyes of nude mice.

Authors:  L White; B C Szirth; W F Benedict
Journal:  Cancer Chemother Pharmacol       Date:  1989       Impact factor: 3.333

Review 4.  Human tumor xenografts as model for drug testing.

Authors:  J Mattern; M Bak; E W Hahn; M Volm
Journal:  Cancer Metastasis Rev       Date:  1988-11       Impact factor: 9.264

5.  Needs for animal models of human diseases of the eye: induced animal models of human ocular disease with particular consideration of ocular melanoma.

Authors:  D M Albert
Journal:  Am J Pathol       Date:  1980-12       Impact factor: 4.307

6.  Pigmented uveal tumours in a transgenic mouse model.

Authors:  T R Kramer; M B Powell; M M Wilson; J Salvatore; H E Grossniklaus
Journal:  Br J Ophthalmol       Date:  1998-08       Impact factor: 4.638

7.  Bone morphogenetic protein 4 (BMP4) signaling in retinoblastoma cells.

Authors:  Maike Haubold; Andreas Weise; Harald Stephan; Nicole Dünker
Journal:  Int J Biol Sci       Date:  2010-11-24       Impact factor: 6.580

Review 8.  Importance of orthotopic transplantation procedures in assessing the effects of transfected genes on human tumor growth and metastasis.

Authors:  R S Kerbel; I Cornil; D Theodorescu
Journal:  Cancer Metastasis Rev       Date:  1991-10       Impact factor: 9.264

Review 9.  Retinoblastoma.

Authors:  Helen Dimaras; Timothy W Corson; David Cobrinik; Abby White; Junyang Zhao; Francis L Munier; David H Abramson; Carol L Shields; Guillermo L Chantada; Festus Njuguna; Brenda L Gallie
Journal:  Nat Rev Dis Primers       Date:  2015-08-27       Impact factor: 52.329

10.  Isochromosome 6p, a unique chromosomal abnormality in retinoblastoma: verification by standard staining techniques, new densitometric methods, and somatic cell hybridization.

Authors:  J Squire; R A Phillips; S Boyce; R Godbout; B Rogers; B L Gallie
Journal:  Hum Genet       Date:  1984       Impact factor: 4.132
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