| Literature DB >> 8449224 |
I L Urbatsch1, R K Sterz, K Peper, W E Trommer.
Abstract
Rats suffering from experimental autoimmune myasthenia gravis (EAMG) induced by previous immunization with foreign acetylcholine receptor (AChR) were treated with AChR-toxin conjugates using the plant toxin gelonin. This led to a marked improvement of clinical symptoms as well as a significant increase in functional AChR compared to untreated rats with EAMG as determined 6 to 10 weeks later. No therapeutic effect was observed after treatment with gelonin or AChR alone. The immune response to irrelevant control antigens was not altered by this treatment.Entities:
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Year: 1993 PMID： 8449224 DOI： 10.1002/eji.1830230332
Source DB: PubMed Journal: Eur J Immunol ISSN： 0014-2980 Impact factor: 5.532