Literature DB >> 8448147

A DNA aptamer which binds to and inhibits thrombin exhibits a new structural motif for DNA.

K Y Wang1, S McCurdy, R G Shea, S Swaminathan, P H Bolton.   

Abstract

The investigation of the three-dimensional structure of the DNA aptamer d(G1G2T3-T4G5G6T7G8T9G10G11T12T13G14G15) which binds to and inhibits thrombin has been carried out by NMR methods. This DNA exhibits a number of long-range NOEs between residues which are not adjacent in sequence, which allowed the determination of the novel tertiary structure adopted. This DNA adopts a highly compact, highly symmetrical structure which consists of two tetrads of guanosine base pairs and three loops. The residues of the tetrads alternate anti-syn-anti-syn. This novel structural motif for DNA may also be relevant to the structure of telomere DNA.

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Year:  1993        PMID： 8448147     DOI： 10.1021/bi00059a003

Source DB:  PubMed          Journal:  Biochemistry        ISSN： 0006-2960            Impact factor:   3.162


  82 in total

1.  The effect of sodium, potassium and ammonium ions on the conformation of the dimeric quadruplex formed by the Oxytricha nova telomere repeat oligonucleotide d(G(4)T(4)G(4)).

Authors:  P Schultze; N V Hud; F W Smith; J Feigon
Journal:  Nucleic Acids Res       Date:  1999-08-01       Impact factor: 16.971

2.  Engineering the quadruplex fold: nucleoside conformation determines both folding topology and molecularity in guanine quadruplexes.

Authors:  Chung-Fei Tang; Richard H Shafer
Journal:  J Am Chem Soc       Date:  2006-05-03       Impact factor: 15.419

3.  Multivariate curve resolution: a powerful tool for the analysis of conformational transitions in nucleic acids.

Authors:  Joaquim Jaumot; Núria Escaja; Raimundo Gargallo; Carlos González; Enrique Pedroso; Romà Tauler
Journal:  Nucleic Acids Res       Date:  2002-09-01       Impact factor: 16.971

4.  Mass spectrometric studies of alkali metal ion binding on thrombin-binding aptamer DNA.

Authors:  Eun Sun Hong; Hye-Joo Yoon; Byungjoo Kim; Yong-Hyeon Yim; Hun-Young So; Seung Koo Shin
Journal:  J Am Soc Mass Spectrom       Date:  2010-04-02       Impact factor: 3.109

5.  The effect on quadruplex stability of North-nucleoside derivatives in the loops of the thrombin-binding aptamer.

Authors:  Anna Aviñó; Stefania Mazzini; Ruben Ferreira; Raimundo Gargallo; Victor E Marquez; Ramon Eritja
Journal:  Bioorg Med Chem       Date:  2012-06-09       Impact factor: 3.641

6.  RNA aptamers specifically interact with the prion protein PrP.

Authors:  S Weiss; D Proske; M Neumann; M H Groschup; H A Kretzschmar; M Famulok; E L Winnacker
Journal:  J Virol       Date:  1997-11       Impact factor: 5.103

7.  Stability and binding properties of a modified thrombin binding aptamer.

Authors:  Bruno Pagano; Luigi Martino; Antonio Randazzo; Concetta Giancola
Journal:  Biophys J       Date:  2007-09-21       Impact factor: 4.033

8.  Hybridization of complementary and homologous peptide nucleic acid oligomers to a guanine quadruplex-forming RNA.

Authors:  Violeta L Marin; Bruce A Armitage
Journal:  Biochemistry       Date:  2006-02-14       Impact factor: 3.162

Review 9.  Functional nucleic acid sensors.

Authors:  Juewen Liu; Zehui Cao; Yi Lu
Journal:  Chem Rev       Date:  2009-05       Impact factor: 60.622

10.  Crystal structure of an RNA aptamer bound to thrombin.

Authors:  Stephen B Long; Meredith B Long; Rebekah R White; Bruce A Sullenger
Journal:  RNA       Date:  2008-10-29       Impact factor: 4.942
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