Literature DB >> 8447933

Mixed haplotypes and autoimmunity.

N R Nygard1, D M McCarthy, J Schiffenbauer, B D Schwartz.   

Abstract

Why do (NZB x NZW)F1 mice develop an autoimmune lupus-like syndrome? The second exons of the class II genes of NZB and NZW are identical to their counterparts of H-2d and H-2u haplotypes. Several lines of evidence suggest that this allows the production of a mixed haplotype molecule, I-E alpha dE beta z, and that this molecule plays a key role in the development of autoimmunity.

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Year:  1993        PMID： 8447933     DOI： 10.1016/0167-5699(93)90058-s

Source DB:  PubMed          Journal:  Immunol Today        ISSN： 0167-5699


  12 in total

Review 1.  Significance of MHC class II haplotypes and IgG Fc receptors in SLE.

Authors:  Sachiko Hirose; Yi Jiang; Hiroyuki Nishimura; Toshikazu Shirai
Journal:  Springer Semin Immunopathol       Date:  2006-09-14

2.  Intrahaplotype and interhaplotype pairing of bovine leukocyte antigen DQA and DQB molecules generate functional DQ molecules important for priming CD4(+) T-lymphocyte responses.

Authors:  Junzo Norimine; Wendy C Brown
Journal:  Immunogenetics       Date:  2005-11-08       Impact factor: 2.846

3.  Peptide-binding motifs of the mixed haplotype Abetaz/Aalphad major histocompatibility complex class II molecule: a restriction element for auto-reactive T cells in (NZBxNZW)F1 mice.

Authors:  M Mine; S Koarada; T Sai; K Miyake; M Kimoto
Journal:  Immunology       Date:  1998-12       Impact factor: 7.397

Review 4.  Genetic studies in systemic autoimmunity and aging.

Authors:  D H Kono; A N Theofilopoulos
Journal:  Immunol Res       Date:  2000       Impact factor: 2.829

5.  Control of separate pathogenic autoantibody responses marks MHC gene contributions to murine lupus.

Authors:  T J Vyse; R K Halterman; S J Rozzo; S Izui; B L Kotzin
Journal:  Proc Natl Acad Sci U S A       Date:  1999-07-06       Impact factor: 11.205

Review 6.  Mechanisms of genetic control of murine systemic lupus erythematosus.

Authors:  S Izui; R Merino; M Iwamoto; L Fossati
Journal:  Springer Semin Immunopathol       Date:  1994

7.  Role of the major histocompatibility complex class II Ea gene in lupus susceptibility in mice.

Authors:  N Ibnou-Zekri; M Iwamoto; L Fossati; P J McConahey; S Izui
Journal:  Proc Natl Acad Sci U S A       Date:  1997-12-23       Impact factor: 11.205

8.  Immune tolerance to autoantibody-derived peptides delays development of autoimmunity in murine lupus.

Authors:  R R Singh; F M Ebling; E E Sercarz; B H Hahn
Journal:  J Clin Invest       Date:  1995-12       Impact factor: 14.808

9.  The Yaa gene abrogates the major histocompatibility complex association of murine lupus in (NZB x BXSB)F1 hybrid mice.

Authors:  R Merino; M Iwamoto; M E Gershwin; S Izui
Journal:  J Clin Invest       Date:  1994-08       Impact factor: 14.808

10.  Dissection of the role of MHC class II A and E genes in autoimmune susceptibility in murine lupus models with intragenic recombination.

Authors:  Danqing Zhang; Keishi Fujio; Yi Jiang; Jingyuan Zhao; Norihiro Tada; Katsuko Sudo; Hiromichi Tsurui; Kazuhiro Nakamura; Kazuhiko Yamamoto; Hiroyuki Nishimura; Toshikazu Shira; Sachiko Hirose
Journal:  Proc Natl Acad Sci U S A       Date:  2004-09-10       Impact factor: 11.205
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