| Literature DB >> 8446960 |
D R Vidal1, P Garrone, J Banchereau.
Abstract
In this study we investigated the effects of exotoxin A on proliferation and differentiation of human B-cells in vitro. Exotoxin A at a concentration of 1 microgram/ml inhibited the proliferation of B-cells preactivated by insolubilized anti-IgM antibody or by formalinized Staphylococcus aureus particles, plus IL-2 or IL-4. B-cell blasts obtained after preactivation of tonsillar B-cells produce IgG and IgM in culture supernatants, and this Ig production is enhanced by IL-2 or IL-4. Exotoxin A inhibited the production of IgG and IgM by the B-blasts at the concentration of 1 microgram/ml.Entities:
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Year: 1993 PMID： 8446960 DOI： 10.1016/0041-0101(93)90353-k
Source DB: PubMed Journal: Toxicon ISSN： 0041-0101 Impact factor: 3.035