| Literature DB >> 8446597 |
C J Li1, L J Zhang, B J Dezube, C S Crumpacker, A B Pardee.
Abstract
Transcription of type 1 human immunodeficiency virus (HIV-1) provirus is governed by the viral long terminal repeat (LTR). Drugs can block HIV-1 replication by inhibiting activity of its LTR. We report that topotecan, beta-lapachone, and curcumin are potent and selective inhibitors of HIV-1 LTR-directed gene expression, at concentrations that have minor effects on cells. At these concentrations, each drug inhibited p24 antigen production in cells either acutely or chronically infected with HIV-1. Their target is transcriptional function of the LTR.Entities:
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Year: 1993 PMID： 8446597 PMCID： PMC45975 DOI： 10.1073/pnas.90.5.1839
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 12.779