Literature DB >> 844582

Alpha-and- beta-activity of O-methylated derivatives of norepinephrine and epinephrine.

W H Vogel, U Trendelenburg.   

Abstract

Metanephrine, iso-metanephrine, normetanephrine and isonormetaephrine were tested for alpha- and beta-activity on various tissues obtained from rats, guinea-pigs and cats. It was found that methylation of the hydroxyl groups of norepinephrine or epinephrine in either the 3- or 4-position markedly reduces or abolishes alpha- and beta-activity with the exception of the nictitating membrane of the cat. This receptor seems to show a tissue difference.

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Year:  1977        PMID： 844582     DOI： 10.1007/BF02124099

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  6 in total

1.  [Actions and physiological importance of metanephrine and normetanephrine].

Authors:  Z M BACQ; J RENSON
Journal:  Arch Int Pharmacodyn Ther       Date:  1961-03-01

2.  COMPARISON OF EFFECTS OF AROMATIC SYMPATHOMIMETIC AMINES ON RABBIT AORTIC STRIP AND RABBIT BLOOD PRESSURE.

Authors:  G D MAENGWYN-DAVIES; T P PRUSS; M WURZEL
Journal:  J Pharmacol Exp Ther       Date:  1965-01       Impact factor: 4.030

3.  Influence of temperature on the sensitivity of the -receptors and the contractility of guinea-pig atrium.

Authors:  D Reinhardt; J Wagner; H J Schümann
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1972       Impact factor: 3.000

4.  Effects of the noradrenaline metabolites on the adrenergic receptors.

Authors:  S Z Langer; M C Rubio
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1973       Impact factor: 3.000

5.  The influence of block and catechol-O-methyl transferase on the sensitivity of isolated organs to catecholamines.

Authors:  U Trendelenburg; D Höhn; K H Graefe; S Pluchino
Journal:  Naunyn Schmiedebergs Arch Pharmakol       Date:  1971

6.  The density of adrenergic innervation of the cat's nictitating membrane as a factor influencing the sensitivity of the isolated preparation to l-norepinephrine.

Authors:  U Trendelenburg; P R Draskóczy; S Pluchino
Journal:  J Pharmacol Exp Ther       Date:  1969-03       Impact factor: 4.030
  6 in total

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