Literature DB >> 844579

Acidic metabolite of prednisolone.

H J Lee.   

Abstract

The metabolic fate of the 17beta-ketol side chain of (21-3H) prednisolone was studied with an enzyme preparation from male golden hamster liver. The acidic metabolite of prednisolone was identified by mass spectrometry as 11beta, 17alpha,20epsilon-trihydroxy-3-oxo-1,4-pregnadien-21-oic acid. The enzyme showed substrate specificity, depending on the nature of substituent on the steroid nucleus.

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Year:  1977        PMID： 844579     DOI： 10.1007/BF02124095

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  5 in total

1.  Acidic steroid metabolites: in vitro metabolism of tritiated progesterone and deoxycorticosterone by rabbit liver.

Authors:  A C Dey; I R Senciall
Journal:  J Steroid Biochem       Date:  1976-03       Impact factor: 4.292

2.  Synthesis of 21-3H-corticosteroids.

Authors:  A K Willingham; C Monder
Journal:  Steroids       Date:  1973-10       Impact factor: 2.668

3.  Isolation and identification of four new carboxylic acid metabolites of cortisol in man.

Authors:  H L Bradlow; B Zumoff; C Monder; H J Lee; L Hellman
Journal:  J Clin Endocrinol Metab       Date:  1973-11       Impact factor: 5.958

4.  The metabolism of [4-14-C]cortisol in patients with collagen diseases.

Authors:  C H Gray; D A Shaw
Journal:  J Endocrinol       Date:  1965-08       Impact factor: 4.286

5.  Studies on human adrenal steroids. I. The effect of corticotropin on components of the free and conjugated plasma C21 adrenal steroid fractions.

Authors:  C M SOUTHCOTT; S K GANDOSSI; A D BARKER; H E BANDY; H MCINTOSH; M DARRACH
Journal:  Can J Biochem Physiol       Date:  1956-03
  5 in total

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