Literature DB >> 8445369

The structure of the 5' terminal cap of the respiratory syncytial virus mRNA.

S Barik1.   

Abstract

The 5' terminal cap structure of the mRNAs of human respiratory syncytial virus synthesized in vitro in the presence of S-adenosyl-L-methionine consists of a 7-methyl guanosine linked to an unmethylated guanosine through a 5'-5' pyrophosphate linkage formed by using the alpha and beta phosphates of GTP. The complete cap structure is m7G (5')ppp(5')Gp ... which is devoid of ribose 2'-O-methylation. Capping, including methylation, is coupled to transcription. These results constitute the first report of a pneumoviral mRNA cap structure.

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Year:  1993        PMID： 8445369     DOI： 10.1099/0022-1317-74-3-485

Source DB:  PubMed          Journal:  J Gen Virol        ISSN： 0022-1317            Impact factor:   3.891


  25 in total

Review 1.  In vitro capping and transcription of rhabdoviruses.

Authors:  Tomoaki Ogino
Journal:  Methods       Date:  2012-06-08       Impact factor: 3.608

2.  Analysis of the gene start and gene end signals of human respiratory syncytial virus: quasi-templated initiation at position 1 of the encoded mRNA.

Authors:  L Kuo; R Fearns; P L Collins
Journal:  J Virol       Date:  1997-07       Impact factor: 5.103

Review 3.  Polymerases of paramyxoviruses and pneumoviruses.

Authors:  Rachel Fearns; Richard K Plemper
Journal:  Virus Res       Date:  2017-01-16       Impact factor: 3.303

4.  Inhibitors of respiratory syncytial virus replication target cotranscriptional mRNA guanylylation by viral RNA-dependent RNA polymerase.

Authors:  Michel Liuzzi; Stephen W Mason; Mireille Cartier; Carol Lawetz; Robert S McCollum; Nathalie Dansereau; Gordon Bolger; Nicole Lapeyre; Yvon Gaudette; Lisette Lagacé; Marie-Josée Massariol; Florence Dô; Paul Whitehead; Lyne Lamarre; Erika Scouten; Josée Bordeleau; Serge Landry; Jean Rancourt; Gulrez Fazal; Bruno Simoneau
Journal:  J Virol       Date:  2005-10       Impact factor: 5.103

5.  Identification of Interferon-Stimulated Gene Proteins That Inhibit Human Parainfluenza Virus Type 3.

Authors:  M A G Rabbani; Michael Ribaudo; Ju-Tao Guo; Sailen Barik
Journal:  J Virol       Date:  2016-11-28       Impact factor: 5.103

6.  Identification of sendai virus L protein amino acid residues affecting viral mRNA cap methylation.

Authors:  Andrea M Murphy; Valery Z Grdzelishvili
Journal:  J Virol       Date:  2008-12-03       Impact factor: 5.103

7.  Polyadenylation-dependent screening assay for respiratory syncytial virus RNA transcriptase activity and identification of an inhibitor.

Authors:  Stephen W Mason; Carol Lawetz; Yvon Gaudette; Florence Dô; Erika Scouten; Lisette Lagacé; Bruno Simoneau; Michel Liuzzi
Journal:  Nucleic Acids Res       Date:  2004-09-08       Impact factor: 16.971

8.  Functional correlations of respiratory syncytial virus proteins to intrinsic disorder.

Authors:  Jillian N Whelan; Krishna D Reddy; Vladimir N Uversky; Michael N Teng
Journal:  Mol Biosyst       Date:  2016-04-26

9.  A conserved motif in region v of the large polymerase proteins of nonsegmented negative-sense RNA viruses that is essential for mRNA capping.

Authors:  Jianrong Li; Amal Rahmeh; Marco Morelli; Sean P J Whelan
Journal:  J Virol       Date:  2007-11-14       Impact factor: 5.103

10.  Rational design of human metapneumovirus live attenuated vaccine candidates by inhibiting viral mRNA cap methyltransferase.

Authors:  Yu Zhang; Yongwei Wei; Xiaodong Zhang; Hui Cai; Stefan Niewiesk; Jianrong Li
Journal:  J Virol       Date:  2014-07-23       Impact factor: 5.103
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