Literature DB >> 8445158

In vitro glucocorticosteroid and mineralocorticosteroid biosynthesis in Conn's adenoma tissues.

A Bogdan1, A Auzéby, P F Plouin, Y Touitou.   

Abstract

The in vitro metabolism of [1,2-3H] deoxycorticosterone (DOC), [1,2-3H] 18-hydroxy-11-deoxycorticosterone (18-OHDOC) and [1,2-3H] 11-deoxycortisol (S) was studied in adrenal adenoma homogenates from patients with primary hyperaldosteronism. Tumor tissues actively converted deoxycorticosterone and 18-hydroxy-11-deoxycorticosterone to 18-hydroxycorticosterone and aldosterone. Yields of cortisol and cortisone were also large showing that the tissues did not lack the zona fasciculata-like 11 beta-hydroxylation ability.

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Year:  1993        PMID： 8445158     DOI： 10.1007/BF03345834

Source DB:  PubMed          Journal:  J Endocrinol Invest        ISSN： 0391-4097            Impact factor:   4.256


  18 in total

1.  18-hydroxylation by human adrenal tissue in vitro.

Authors:  A F De Nicola; H Traikov; M K Birmingham; J D Palmer; D W Ruddick
Journal:  J Clin Endocrinol Metab       Date:  1970-03       Impact factor: 5.958

2.  Isolation and identification of 18-hydroxycortisol from the urine of patients with primary aldosteronism.

Authors:  M D Chu; S Ulick
Journal:  J Biol Chem       Date:  1982-03-10       Impact factor: 5.157

3.  Defective fasciculata zone function as the mechanism of glucocorticoid-remediable aldosteronism.

Authors:  S Ulick; C K Chan; J R Gill; M Gutkin; L Letcher; F Mantero; M I New
Journal:  J Clin Endocrinol Metab       Date:  1990-11       Impact factor: 5.958

4.  Aldosterone synthase cytochrome P-450 expressed in the adrenals of patients with primary aldosteronism.

Authors:  T Ogishima; H Shibata; H Shimada; F Mitani; H Suzuki; T Saruta; Y Ishimura
Journal:  J Biol Chem       Date:  1991-06-15       Impact factor: 5.157

5.  Aminoglutethimide and glutethimide: effects on 18-hydroxycorticosterone biosynthesis by human and sheep adrenals in vitro.

Authors:  Y Touitou; A Bogdan; J C Legrand; P Desgrez
Journal:  Acta Endocrinol (Copenh)       Date:  1975-11

6.  The product of the CYP11B2 gene is required for aldosterone biosynthesis in the human adrenal cortex.

Authors:  K M Curnow; M T Tusie-Luna; L Pascoe; R Natarajan; J L Gu; J L Nadler; P C White
Journal:  Mol Endocrinol       Date:  1991-10

7.  Content and biosynthesis of cortisol in aldosterone-producing adenomas.

Authors:  A Carballeira; L M Fishman; J W Brown; D Trujillo
Journal:  J Lab Clin Med       Date:  1989-08

Review 8.  Adrenocortical factors in hypertension. I. Significance of 18-hydroxy-11-deoxycorticosterone.

Authors:  S Ulick
Journal:  Am J Cardiol       Date:  1976-11-23       Impact factor: 2.778

9.  Glucocorticoid and mineralocorticoid pathways in two adrenocortical carcinomas: comparison of the effects of o,p'-dichlorodiphenyldichloroethane, aminoglutethimide and 2-p-aminophenyl-2-phenylethylamine in vitro.

Authors:  Y Touitou; A Bogdan; A Auzeby; J P Dommergues
Journal:  J Endocrinol       Date:  1979-07       Impact factor: 4.286

10.  In vitro biosynthesis of 18-hydroxy-11-deoxycorticosterone from deoxycorticosterone by human adrenal glands removed from patients with hypercorticism.

Authors:  Y Touitou; A Bogdan; J P Luton
Journal:  Clin Endocrinol (Oxf)       Date:  1979-07       Impact factor: 3.478
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  1 in total

1.  Aldosterone and cortisol co-secreting bifunctional adrenal cortical carcinoma: A rare event.

Authors:  Puskar Shyam Chowdhury; Prasant Nayak; Srinivasan Gurumurthy; Deepak David
Journal:  Indian J Urol       Date:  2014-07
  1 in total

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