Literature DB >> 8444654

Synergy of cefotaxime and fosfomycin against penicillin-resistant pneumococci.

V Barakett1, D Lesage, F Delisle, B Burghoffer, G Richard, P Vergez, J C Petit.   

Abstract

The killing kinetics of cefotaxime and fosfomycin, alone and in combination, against seven clinical isolates of penicillin-resistant pneumococci were studied. The antibiotics were tested at 1 x, 2 x and 4 x the MIC for each individual isolate. The results showed a synergic interaction of the two antibiotics for three of the seven strains. This strategy may be useful clinically.

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Year:  1993        PMID： 8444654     DOI： 10.1093/jac/31.1.105

Source DB:  PubMed          Journal:  J Antimicrob Chemother        ISSN： 0305-7453            Impact factor:   5.790


  6 in total

1.  In vivo activity and pharmacodynamics of amoxicillin in combination with fosfomycin in fibrin clots infected with highly penicillin-resistant Streptococcus pneumoniae.

Authors:  P Chavanet; N Peyrard; A Pechinot; M Buisson; M Duong; C Neuwirth; A Kazmierczak; H Portier
Journal:  Antimicrob Agents Chemother       Date:  1996-09       Impact factor: 5.191

2.  In vivo activity and pharmacodynamics of cefotaxime or ceftriaxone in combination with fosfomycin in fibrin clots infected with highly penicillin-resistant Streptococcus pneumoniae.

Authors:  P Chavanet; H Beloeil; A Pechinot; F Duigou; J C Buisson; M Duong; C Neuwirth; A Kazmierczak; H Portier
Journal:  Antimicrob Agents Chemother       Date:  1995-08       Impact factor: 5.191

3.  In vitro killing activities of antibiotics at clinically achievable concentrations in cerebrospinal fluid against penicillin-resistant Streptococcus pneumoniae isolated from children with meningitis.

Authors:  C P Doit; S P Bonacorsi; A J Fremaux; G Sissia; R Cohen; P L Geslin; E H Bingen
Journal:  Antimicrob Agents Chemother       Date:  1994-11       Impact factor: 5.191

Review 4.  Cefotaxime. A reappraisal of its antibacterial activity and pharmacokinetic properties, and a review of its therapeutic efficacy when administered twice daily for the treatment of mild to moderate infections.

Authors:  R N Brogden; C M Spencer
Journal:  Drugs       Date:  1997-03       Impact factor: 9.546

5.  Evaluation of antimicrobial regimens for treatment of experimental penicillin- and cephalosporin-resistant pneumococcal meningitis.

Authors:  I R Friedland; M Paris; S Ehrett; S Hickey; K Olsen; G H McCracken
Journal:  Antimicrob Agents Chemother       Date:  1993-08       Impact factor: 5.191

6.  In vitro interactions between different beta-lactam antibiotics and fosfomycin against bloodstream isolates of enterococci.

Authors:  M Pestel; E Martin; C Aucouturier; J F Lemeland; F Caron
Journal:  Antimicrob Agents Chemother       Date:  1995-10       Impact factor: 5.191
  6 in total

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