Literature DB >> 8444218

The immune response in iron-deficient young children: effect of iron supplementation on cell-mediated immunity.

H Thibault1, P Galan, F Selz, P Preziosi, C Olivier, J Badoual, S Hercberg.   

Abstract

The effects of iron deficiency on immunity remain controversial. This study was designed to assess the impact of iron supplementation on the immune status, in 81 children aged 6 months-3 years, at high risk for iron deficiency, using a longitudinal double blind randomised and placebo-controlled study. Lymphocytes of iron-deficient children produced less interleukin-2 in vitro. Iron supplementation for 2 months increased mean corpuscular volume, serum ferritin and serum transferrin, but had no effect on the parameters of T-cell mediated immunity. The lower interleukin-2 levels in iron-deficient suggest that cell-mediated immunity may be impaired in iron deficiency.

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Year:  1993        PMID： 8444218     DOI： 10.1007/bf02072487

Source DB:  PubMed          Journal:  Eur J Pediatr        ISSN： 0340-6199            Impact factor:   3.183


  24 in total

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Authors:  S J Oppenheimer
Journal:  Acta Paediatr Scand Suppl       Date:  1989

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Authors:  M J Farthing
Journal:  Acta Paediatr Scand Suppl       Date:  1989
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  18 in total

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Authors:  R J Harris
Journal:  Arch Dis Child       Date:  2004-02       Impact factor: 3.791

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Journal:  Eur J Clin Microbiol Infect Dis       Date:  2013-04-18       Impact factor: 3.267

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7.  Evaluation of iron deficiency as a nutritional adaptation to infectious disease: an evolutionary medicine perspective.

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Review 9.  Iron Nutriture of the Fetus, Neonate, Infant, and Child.

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10.  Impact of IgG response to malaria-specific antigens and immunity against malaria in pre-school children in Ghana. A cluster randomized, placebo-controlled trial.

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