Literature DB >> 8443685

Aromatase activity in human osteoblast-like osteosarcoma cell.

S Tanaka1, M Haji, Y Nishi, T Yanase, R Takayanagi, H Nawata.   

Abstract

Aromatase activity was studied in cultured human osteosarcoma cell (HOS). HOS was incubated from 12 to 72 hours with 10(-10) M-10(-5) M dexamethasone. Aromatase activity was determined by measuring [3H]H2O released upon the conversion of [1 beta-3H]androstenedione to estrone. HOS showed aromatase activity, and apparent km for [1 beta-3H]androstenedione was 4.46 +/- 0.98 nm (mean +/- SD). The aromatase activity was significantly increased by 10(-9) M-10(-5) M dexamethasone in a dose-dependent manner. Dexamethasone increased Vmax of aromatase activity but did not change its km value. These results suggest that osteoblastic cells have aromatase activity which is regulated by glucocorticoid, and directly convert androgen to estrogen in itself.

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Year:  1993        PMID： 8443685     DOI： 10.1007/bf00308318

Source DB:  PubMed          Journal:  Calcif Tissue Int        ISSN： 0171-967X            Impact factor:   4.333


  17 in total

1.  Osteoclasts isolated from membranous bone in children exhibit nuclear estrogen and progesterone receptors.

Authors:  J M Pensler; J A Radosevich; R Higbee; C B Langman
Journal:  J Bone Miner Res       Date:  1990-08       Impact factor: 6.741

2.  Effect of surgical menopause and estrogen replacement on cytokine release from human blood mononuclear cells.

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Journal:  Proc Natl Acad Sci U S A       Date:  1991-06-15       Impact factor: 11.205

3.  Estrogen binding, receptor mRNA, and biologic response in osteoblast-like osteosarcoma cells.

Authors:  B S Komm; C M Terpening; D J Benz; K A Graeme; A Gallegos; M Korc; G L Greene; B W O'Malley; M R Haussler
Journal:  Science       Date:  1988-07-01       Impact factor: 47.728

4.  Induction of testicular aromatization by luteinizing hormone in mature rats.

Authors:  L E Valladares; A H Payne
Journal:  Endocrinology       Date:  1979-08       Impact factor: 4.736

5.  Source of estrogen production in postmenopausal women.

Authors:  J M Grodin; P K Siiteri; P C MacDonald
Journal:  J Clin Endocrinol Metab       Date:  1973-02       Impact factor: 5.958

6.  RU486 inhibits induction of aromatase by dexamethasone via glucocorticoid receptor in cultured human skin fibroblasts.

Authors:  H Nawata; K Ono; M Ohashi; K Kato; H Ibayashi
Journal:  J Steroid Biochem       Date:  1988-01       Impact factor: 4.292

7.  Aromatization of androstenedione by human adipose tissue stromal cells in monolayer culture.

Authors:  G E Ackerman; M E Smith; C R Mendelson; P C MacDonald; E R Simpson
Journal:  J Clin Endocrinol Metab       Date:  1981-08       Impact factor: 5.958

8.  Concentration of oestrogens and androgens in human ovarian venous plasma and follicular fluid throughout the menstrual cycle.

Authors:  K P McNatty; D T Baird; A Bolton; P Chambers; C S Corker; H McLean
Journal:  J Endocrinol       Date:  1976-10       Impact factor: 4.286

9.  Effects of aging and obesity on aromatase activity of human adipose cells.

Authors:  W H Cleland; C R Mendelson; E R Simpson
Journal:  J Clin Endocrinol Metab       Date:  1985-01       Impact factor: 5.958

10.  Effect of excess endogenous androgens on bone density in young women.

Authors:  J R Buchanan; P Hospodar; C Myers; P Leuenberger; L M Demers
Journal:  J Clin Endocrinol Metab       Date:  1988-11       Impact factor: 5.958
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  10 in total

1.  The gene for aromatase, a rate-limiting enzyme for local estrogen biosynthesis, is a downstream target gene of Runx2 in skeletal tissues.

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Journal:  Mol Cell Biol       Date:  2010-03-15       Impact factor: 4.272

2.  Aromatization of androgens is important for skeletal maintenance of aged male rats.

Authors:  D Vanderschueren; E Van Herck; R De Coster; R Bouillon
Journal:  Calcif Tissue Int       Date:  1996-09       Impact factor: 4.333

Review 3.  Testosterone therapy in men: clinical and pharmacological perspectives.

Authors:  A Gambineri; R Pasquali
Journal:  J Endocrinol Invest       Date:  2000-03       Impact factor: 4.256

Review 4.  New insights into osteoporosis: the bone-fat connection.

Authors:  M Kawai; F J A de Paula; C J Rosen
Journal:  J Intern Med       Date:  2012-07-29       Impact factor: 8.989

Review 5.  Androgens and bone.

Authors:  D Vanderschueren; R Bouillon
Journal:  Calcif Tissue Int       Date:  1995-05       Impact factor: 4.333

Review 6.  Marrow fat and the bone microenvironment: developmental, functional, and pathological implications.

Authors:  Clifford J Rosen; Cheryl Ackert-Bicknell; Juan Pablo Rodriguez; Ana Maria Pino
Journal:  Crit Rev Eukaryot Gene Expr       Date:  2009       Impact factor: 1.807

7.  Regulation of interleukin-6, osteoclastogenesis, and bone mass by androgens. The role of the androgen receptor.

Authors:  T Bellido; R L Jilka; B F Boyce; G Girasole; H Broxmeyer; S A Dalrymple; R Murray; S C Manolagas
Journal:  J Clin Invest       Date:  1995-06       Impact factor: 14.808

8.  Aromatase activity and bone loss in men.

Authors:  Daniela Merlotti; Luigi Gennari; Konstantinos Stolakis; Ranuccio Nuti
Journal:  J Osteoporos       Date:  2011-06-24

9.  Eurycoma longifolia: Medicinal Plant in the Prevention and Treatment of Male Osteoporosis due to Androgen Deficiency.

Authors:  Nadia Mohd Effendy; Norazlina Mohamed; Norliza Muhammad; Isa Naina Mohamad; Ahmad Nazrun Shuid
Journal:  Evid Based Complement Alternat Med       Date:  2012-07-15       Impact factor: 2.629

Review 10.  Role of RUNX2 in Breast Carcinogenesis.

Authors:  Daniel Wysokinski; Janusz Blasiak; Elzbieta Pawlowska
Journal:  Int J Mol Sci       Date:  2015-09-02       Impact factor: 5.923
  10 in total

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