Literature DB >> 8441658

Functional analysis of the human neurofilament light chain gene promoter.

K Yazdanbakhsh1, P Fraser, D Kioussis, M Vidal, F Grosveld, M Lindenbaum.   

Abstract

We have carried out a structural and functional analysis on the human NF-L (H-NF-L) gene. It contains a methylation-free island, spanning the 5' flanking sequences and the first exon and a number of neuronal-specific DNase I hypersensitive sites have been identified in the upstream region as well as within the body of the gene. Analysis in cell lines and transgenic mice using a combination of these sites has revealed the presence of a conserved element(s) between -300bp and -190bp which is required for neuronal-specific expression.

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Year:  1993        PMID： 8441658      PMCID： PMC309139          DOI： 10.1093/nar/21.3.455

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  38 in total

1.  Isolation of the chicken middle-molecular weight neurofilament (NF-M) gene and characterization of its promoter.

Authors:  D Zopf; B Dineva; H Betz; E D Gundelfinger
Journal:  Nucleic Acids Res       Date:  1990-02-11       Impact factor: 16.971

2.  Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids.

Authors:  A J Berk; P A Sharp
Journal:  Cell       Date:  1977-11       Impact factor: 41.582

3.  A cell type-preferred silencer element that controls the neural-specific expression of the SCG10 gene.

Authors:  N Mori; R Stein; O Sigmund; D J Anderson
Journal:  Neuron       Date:  1990-04       Impact factor: 17.173

4.  Transgenic mice expressing beta-galactosidase in mature neurons under neuron-specific enolase promoter control.

Authors:  S Forss-Petter; P E Danielson; S Catsicas; E Battenberg; J Price; M Nerenberg; J G Sutcliffe
Journal:  Neuron       Date:  1990-08       Impact factor: 17.173

5.  Clonal cell lines from the rat central nervous system.

Authors:  D Schubert; S Heinemann; W Carlisle; H Tarikas; B Kimes; J Patrick; J H Steinbach; W Culp; B L Brandt
Journal:  Nature       Date:  1974-05-17       Impact factor: 49.962

6.  Specific neuronal expression of human NGF receptors in the basal forebrain and cerebellum of transgenic mice.

Authors:  N Patil; E Lacy; M V Chao
Journal:  Neuron       Date:  1990-03       Impact factor: 17.173

7.  Ectopic expression of Thy-1 in the kidneys of transgenic mice induces functional and proliferative abnormalities.

Authors:  G Kollias; D J Evans; M Ritter; J Beech; R Morris; F Grosveld
Journal:  Cell       Date:  1987-10-09       Impact factor: 41.582

8.  Position-independent, high-level expression of the human beta-globin gene in transgenic mice.

Authors:  F Grosveld; G B van Assendelft; D R Greaves; G Kollias
Journal:  Cell       Date:  1987-12-24       Impact factor: 41.582

9.  Transcriptional and post-transcriptional effects of nerve growth factor on expression of the three neurofilament subunits in PC-12 cells.

Authors:  M H Lindenbaum; S Carbonetto; F Grosveld; D Flavell; W E Mushynski
Journal:  J Biol Chem       Date:  1988-04-25       Impact factor: 5.157

10.  Nerve growth factor activates Thy-1 and neurofilament gene transcription in rat PC12 cells.

Authors:  G Dickson; H Prentice; J P Julien; G Ferrari; A Leon; F S Walsh
Journal:  EMBO J       Date:  1986-12-20       Impact factor: 11.598
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  2 in total

1.  Characterization of DNase I hypersensitive sites in the mouse 68-kDa neurofilament gene.

Authors:  R Kure; T R Ivanov; I R Brown
Journal:  Neurochem Res       Date:  1996-06       Impact factor: 3.996

2.  RE1 silencing transcription factor is involved in regulating neuron-specific expression of alpha-internexin and neurofilament genes.

Authors:  Gee Y Ching; Ronald K H Liem
Journal:  J Neurochem       Date:  2009-03-23       Impact factor: 5.372
  2 in total

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