OBJECTIVE: To define the arthritogenic effects of incomplete Freund's adjuvant (ICFA) injections in DA rats. METHODS: ICFA was injected into DA rats and other inbred rat strains. The severity of arthritis was scored and associated changes in weight recorded. RESULTS: After ICFA injection a mild transient symmetric arthritis developed in 15/22 (68%) of the DA rats observed for greater than 4 weeks. Histologic examination of the observed arthritis showed edema and neutrophil infiltrates with some lymphocytes and plasma cells. No arthritis developed in DA rats given normal saline injections nor in Lewis, DA.1N and WF.1N rats given ICFA. CONCLUSIONS: Injection of DA rats with ICFA alone can produce arthritis.
OBJECTIVE: To define the arthritogenic effects of incomplete Freund's adjuvant (ICFA) injections in DA rats. METHODS:ICFA was injected into DA rats and other inbred rat strains. The severity of arthritis was scored and associated changes in weight recorded. RESULTS: After ICFA injection a mild transient symmetric arthritis developed in 15/22 (68%) of the DA rats observed for greater than 4 weeks. Histologic examination of the observed arthritis showed edema and neutrophil infiltrates with some lymphocytes and plasma cells. No arthritis developed in DA rats given normal saline injections nor in Lewis, DA.1N and WF.1N rats given ICFA. CONCLUSIONS: Injection of DA rats with ICFA alone can produce arthritis.
Authors: J C Lorentzen; A Glaser; L Jacobsson; J Galli; H Fakhrai-rad; L Klareskog; H Luthman Journal: Proc Natl Acad Sci U S A Date: 1998-05-26 Impact factor: 11.205
Authors: A G van de Langerijt; P L van Lent; A R Hermus; L B van de Putte; W B van den Berg Journal: Clin Exp Immunol Date: 1993-10 Impact factor: 4.330