Literature DB >> 8440087

The development of Pneumocystis carinii pneumonia in germ-free rats requires immunosuppression and exposure to the Pneumocystis carinii organism.

L Wolff1, S Horch, D Gemsa.   

Abstract

Adult germ-free rats treated with dexamethasone and exposed to a non-sterile environment did not harbor or develop Pneumocystis carinii cysts or trophozoites after 10 weeks of immunosuppression. Only when they were exposed to infected, conventional rats and treated with dexamethasone for 8 weeks or longer, did adult germ-free rats develop P. carinii infection.

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Year:  1993        PMID： 8440087     DOI： 10.1016/0147-9571(93)90063-b

Source DB:  PubMed          Journal:  Comp Immunol Microbiol Infect Dis        ISSN： 0147-9571            Impact factor:   2.268


  5 in total

Review 1.  Infections in the immunosuppressed host.

Authors:  M Patricia George; Henry Masur; Karen A Norris; Scott M Palmer; Cornelius J Clancy; John F McDyer
Journal:  Ann Am Thorac Soc       Date:  2014-08

Review 2.  The ecology of pneumocystis: perspectives, personal recollections, and future research opportunities.

Authors:  Peter D Walzer
Journal:  J Eukaryot Microbiol       Date:  2013-09-03       Impact factor: 3.346

Review 3.  Colonization by Pneumocystis jirovecii and its role in disease.

Authors:  Alison Morris; Karen A Norris
Journal:  Clin Microbiol Rev       Date:  2012-04       Impact factor: 26.132

Review 4.  Pneumocystis Pneumonia: Pitfalls and Hindrances to Establishing a Reliable Animal Model.

Authors:  Adélaïde Chesnay; Christophe Paget; Nathalie Heuzé-Vourc'h; Thomas Baranek; Guillaume Desoubeaux
Journal:  J Fungi (Basel)       Date:  2022-01-27

5.  Pneumocystis colonization in immunocompetent and simian immunodeficiency virus-infected cynomolgus macaques.

Authors:  Heather M Kling; Timothy W Shipley; Sangita Patil; Alison Morris; Karen A Norris
Journal:  J Infect Dis       Date:  2009-01-01       Impact factor: 5.226
  5 in total

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