Literature DB >> 8439556

Alteration of superhelical state of DNA by aluminium (Al).

K S Rao1, B S Rao, D Vishnuvardhan, K V Prasad.   

Abstract

The effect of aluminium (Al) on the supercoiled state of pUC18 DNA was studied by ethidium bromide fluorescence and agarose gel electrophoresis. Al at physiologically relevant concentrations relaxed the intact supercoiled DNA as well as the topoisomers induced by chloroquine. EDTA prevented the unwinding effect of Al on supercoiled DNA. Al did not alter the mobility of linear DNA in agarose gels. The implications of this finding in neurological disorders are discussed.

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Year:  1993        PMID： 8439556     DOI： 10.1016/0167-4781(93)90263-d

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  5 in total

1.  Evaluation of the genotoxicity of waters impacted by domestic and industrial effluents of a highly industrialized region of São Paulo State, Brazil, by the comet assay in HTC cells.

Authors:  Bárbara Cassu Manzano; Matheus Mantuanelli Roberto; Márcia Miyuki Hoshina; Amauri Antônio Menegário; Maria Aparecida Marin-Morales
Journal:  Environ Sci Pollut Res Int       Date:  2014-08-23       Impact factor: 4.223

2.  Buccal micronucleus cytome assay of populations under chronic heavy metal and other metal exposure along the Santiago River, Mexico.

Authors:  B C Gómez-Meda; G M Zúñiga-González; L V Sánchez-Orozco; A L Zamora-Perez; J P Rojas-Ramírez; A D Rocha-Muñoz; A A Sobrevilla-Navarro; M A Arellano-Avelar; A A Guerrero-de León; J S Armendáriz-Borunda; M G Sánchez-Parada
Journal:  Environ Monit Assess       Date:  2017-09-26       Impact factor: 2.513

3.  27Al-NMR studies of aluminum transport across yeast cell membranes.

Authors:  K S Rao; K R Easwaran
Journal:  Mol Cell Biochem       Date:  1997-10       Impact factor: 3.396

4.  First evidence for helical transitions in supercoiled DNA by amyloid Beta Peptide (1-42) and aluminum: a new insight in understanding Alzheimer's disease.

Authors:  Muralidhar L Hegde; Suram Anitha; Kallur S Latha; Mohammed S Mustak; Reuven Stein; Rivka Ravid; K S Jagannatha Rao
Journal:  J Mol Neurosci       Date:  2004       Impact factor: 3.444

5.  Modulations in antioxidant enzymes in different tissues of marine bivalve Perna viridis during heavy metal exposure.

Authors:  N T Prakash; K S Rao
Journal:  Mol Cell Biochem       Date:  1995-05-24       Impact factor: 3.396
  5 in total

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