| Literature DB >> 8438897 |
Abstract
Erythrocytes in the aged have a decreased life span. The properties of the red blood cells of old individuals are compared to those of the cells of young individuals. In young individuals, removal of the normal erythrocyte at the end of its lifespan is determined by a signal(s) due to (1) modified phospholipids, (2) modified carbohydrate residues, and/or (3) modified proteins. Similar changes may occur in the erythrocytes of old individuals but at a greater rate. In particular, the enhanced degradation of band 3 protein by calpain may provide a senescence signal.Entities:
Mesh:
Year: 1993 PMID: 8438897 DOI: 10.1002/ajh.2830420302
Source DB: PubMed Journal: Am J Hematol ISSN: 0361-8609 Impact factor: 10.047