Literature DB >> 8438664

The association of age with gastric emptying.

N Gainsborough1, V L Maskrey, M L Nelson, J Keating, R A Sherwood, S H Jackson, C G Swift.   

Abstract

Gastric emptying is important as a rate-limiting step in the absorption of orally administered drugs. Paracetamol absorption kinetics were used to compare gastric emptying in 19 fit elderly and 19 fit young volunteers. The results showed no significant difference in any of the derived parameters (t1/2abs, tlag and tmax) between the two groups. These results suggest that ageing does not impair this rate-limiting step in drug absorption.

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Year:  1993        PMID： 8438664     DOI： 10.1093/ageing/22.1.37

Source DB:  PubMed          Journal:  Age Ageing        ISSN： 0002-0729            Impact factor:   10.668


  13 in total

Review 1.  Age-related changes in pharmacokinetics and pharmacodynamics: basic principles and practical applications.

Authors:  A A Mangoni; S H D Jackson
Journal:  Br J Clin Pharmacol       Date:  2004-01       Impact factor: 4.335

Review 2.  Cardiovascular drug therapy in elderly patients: specific age-related pharmacokinetic, pharmacodynamic and therapeutic considerations.

Authors:  Arduino A Mangoni
Journal:  Drugs Aging       Date:  2005       Impact factor: 3.923

Review 3.  The aging oesophagus.

Authors:  J Tack; G Vantrappen
Journal:  Gut       Date:  1997-10       Impact factor: 23.059

4.  Repository Describing an Aging Population to Inform Physiologically Based Pharmacokinetic Models Considering Anatomical, Physiological, and Biological Age-Dependent Changes.

Authors:  Felix Stader; Marco Siccardi; Manuel Battegay; Hannah Kinvig; Melissa A Penny; Catia Marzolini
Journal:  Clin Pharmacokinet       Date:  2019-04       Impact factor: 6.447

5.  Treating older people.

Authors:  Ken Woodhouse
Journal:  Eur J Clin Pharmacol       Date:  2013-05-03       Impact factor: 2.953

6.  Effect of aging on transpyloric flow, gastric emptying, and intragastric distribution in healthy humans--impact on glycemia.

Authors:  Deirdre O'Donovan; Trygve Hausken; Yong Lei; Antonietta Russo; Jennifer Keogh; Michael Horowitz; Karen L Jones
Journal:  Dig Dis Sci       Date:  2005-04       Impact factor: 3.199

7.  Gastric emptying following brain injury: effects of choice of sedation and intracranial pressure.

Authors:  C J McArthur; T Gin; I M McLaren; J A Critchley; T E Oh
Journal:  Intensive Care Med       Date:  1995-07       Impact factor: 17.440

Review 8.  Medication prescribing in frail older people.

Authors:  Ruth E Hubbard; M Sinead O'Mahony; Kenneth W Woodhouse
Journal:  Eur J Clin Pharmacol       Date:  2012-09-11       Impact factor: 2.953

9.  Influence of age on the enantiomeric disposition of ibuprofen in healthy volunteers.

Authors:  Soo Choon Tan; Bhavesh K Patel; Stephen H D Jackson; Cameron G Swift; Andrew J Hutt
Journal:  Br J Clin Pharmacol       Date:  2003-06       Impact factor: 4.335

10.  Glucose absorption and gastric emptying in critical illness.

Authors:  Marianne J Chapman; Robert J L Fraser; Geoffrey Matthews; Antonietta Russo; Max Bellon; Laura K Besanko; Karen L Jones; Ross Butler; Barry Chatterton; Michael Horowitz
Journal:  Crit Care       Date:  2009-08-27       Impact factor: 9.097
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