Literature DB >> 8438233

Experimental application of top-down control analysis to metabolic systems.

P A Quant1.   

Abstract

Metabolic control analysis (MCA) has provided the language and framework for quantitative study of control over flux, or over metabolites, by individual enzymes of a pathway. By contrast, top-down control analysis (TDCA) yields an immediate overview of the control structure of the whole system of interest, giving information about the control exercised by large sections of complex pathways. Unlike MCA, TDCA does not rely on the use of specific inhibitors or genetic manipulation to determine control coefficients. The method and an application of TDCA to ketogenesis are described.

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Year:  1993        PMID： 8438233     DOI： 10.1016/0968-0004(93)90084-z

Source DB:  PubMed          Journal:  Trends Biochem Sci        ISSN： 0968-0004            Impact factor:   13.807


  10 in total

1.  Elasticity analysis and design for large metabolic responses produced by changes in enzyme activities.

Authors:  Fernando Ortega; Luis Acerenza
Journal:  Biochem J       Date:  2002-10-01       Impact factor: 3.857

Review 2.  Nutrient uptake by microorganisms according to kinetic parameters from theory as related to cytoarchitecture.

Authors:  D K Button
Journal:  Microbiol Mol Biol Rev       Date:  1998-09       Impact factor: 11.056

3.  Control analysis applied to the whole body: control by body organs over plasma concentrations and organ fluxes of substances in the blood.

Authors:  G C Brown
Journal:  Biochem J       Date:  1994-01-01       Impact factor: 3.857

4.  Kinetics and control of oxidative phosphorylation in rat liver mitochondria after chronic ethanol feeding.

Authors:  A Marcinkeviciute; V Mildaziene; S Crumm; O Demin; J B Hoek; B Kholodenko
Journal:  Biochem J       Date:  2000-07-15       Impact factor: 3.857

5.  Enzymatic phosphorylation of muscle glycogen synthase: a mechanism for maintenance of metabolic homeostasis.

Authors:  R G Shulman; D L Rothman
Journal:  Proc Natl Acad Sci U S A       Date:  1996-07-23       Impact factor: 11.205

6.  Flux control exerted by overt carnitine palmitoyltransferase over palmitoyl-CoA oxidation and ketogenesis is lower in suckling than in adult rats.

Authors:  S Krauss; C V Lascelles; V A Zammit; P A Quant
Journal:  Biochem J       Date:  1996-10-15       Impact factor: 3.857

7.  Control mechanisms operating for lipid biosynthesis differ in oil-palm (Elaeis guineensis Jacq.) and olive (Olea europaea L.) callus cultures.

Authors:  Umi S Ramli; Darren S Baker; Patti A Quant; John L Harwood
Journal:  Biochem J       Date:  2002-06-01       Impact factor: 3.857

8.  Control analysis of lipid biosynthesis in tissue cultures from oil crops shows that flux control is shared between fatty acid synthesis and lipid assembly.

Authors:  Umi S Ramli; Darren S Baker; Patti A Quant; John L Harwood
Journal:  Biochem J       Date:  2002-06-01       Impact factor: 3.857

Review 9.  Metabolism as a complex genetic trait, a systems biology approach: implications for inborn errors of metabolism and clinical diseases.

Authors:  Jerry Vockley
Journal:  J Inherit Metab Dis       Date:  2008-10-05       Impact factor: 4.982

Review 10.  In vivo regulation of muscle glycogen synthase and the control of glycogen synthesis.

Authors:  R G Shulman; G Bloch; D L Rothman
Journal:  Proc Natl Acad Sci U S A       Date:  1995-09-12       Impact factor: 11.205
  10 in total

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